Diverse variola virus (smallpox) strains were widespread in northern Europe in the Viking Age
| Autor: | Anders J. Hansen, Yvonne Magnusson, Martin Sikora, Barbara Mühlemann, Ceri Falys, Eske Willerslev, Jan Bill, Peter de Barros Damgaard, Marie Louise Jørkov, Geoffrey L. Smith, Christian Drosten, Lasse Vinner, Morten E. Allentoft, Hannes Schroeder, Alexandra P. Buzhilova, Sofie Holtsmark Nielsen, Vyacheslav Moiseyev, Terry Jones, Ashot Margaryan, Constanza de la Fuente Castro, Lisa Strand, Gerd Sutter, Ron A. M. Fouchier, Tamara Pushkina, Helene Wilhelmson, Palle Østergaard Sørensen, Valeri Khartanovich, Ingrid Gustin, Derek J. Smith |
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| Přispěvatelé: | Virology |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Most recent common ancestor
viruses Genome Viral Biology complex mixtures 03 medical and health sciences medicine Smallpox Humans 0601 history and archaeology Clade 030304 developmental biology 0303 health sciences Multidisciplinary 060102 archaeology virus diseases 06 humanities and the arts Biological evolution Variola virus medicine.disease Virology Biological Evolution History Medieval 3. Good health Europe Viking Age Host adaptation |
| Zdroj: | Mühlemann, B, Vinner, L, Margaryan, A, Wilhelmson, H, de la Fuente Castro, C, Allentoft, M E, de Barros Damgaard, P, Hansen, A J, Holtsmark Nielsen, S, Strand, L M, Bill, J, Buzhilova, A, Pushkina, T, Falys, C, Khartanovich, V, Moiseyev, V, Jørkov, M L S, Østergaard Sørensen, P, Magnusson, Y, Gustin, I, Schroeder, H, Sutter, G, Smith, G L, Drosten, C, Fouchier, R A M, Smith, D J, Willerslev, E, Jones, T C & Sikora, M 2020, ' Diverse variola virus (smallpox) strains were widespread in northern Europe in the Viking Age ', Science (New York, N.Y.), vol. 369, no. 6502, eaaw8977 . https://doi.org/10.1126/science.aaw8977 369:eaaw8977 Science Mühlemann, B, Vinner, L, Margaryan, A, Wilhelmson, H, de la Fuente Castro, C, Allentoft, M E, de Barros Damgaard, P, Hansen, A J, Holtsmark Nielsen, S, Strand, L M, Bill, J, Buzhilova, A, Pushkina, T, Falys, C, Khartanovich, V, Moiseyev, V, Jørkov, M L S, Østergaard Sørensen, P, Magnusson, Y, Gustin, I, Schroeder, H, Sutter, G, Smith, G L, Drosten, C, Fouchier, R A M, Smith, D J, Willerslev, E, Jones, T C & Sikora, M 2020, ' Diverse variola virus (smallpox) strains were widespread in northern Europe in the Viking Age ', Science (New York, N.Y.), vol. 369, no. 6502, pp. 1-12 . https://doi.org/10.1126/science.aaw8977 Science, 369(6502):eaaw8977. American Association for the Advancement of Science |
| ISSN: | 0036-8075 |
| DOI: | 10.1126/science.aaw8977 |
| Popis: | Humans have a notable capacity to withstand the ravages of infectious diseases. Smallpox killed millions of people but drove Jenner's invention of vaccination, which eventually led to the annihilation of this virus, declared in 1980. To investigate the history of smallpox, Mühlemann et al. obtained high-throughput shotgun sequencing data from 1867 human remains ranging from >31,000 to 150 years ago (see the Perspective by Alcamí). Thirteen positive samples emerged, 11 of which were northern European Viking Age people (6th to 7th century CE). Although the sequences were patchy and incomplete, four could be used to infer a phylogenetic tree. This showed distinct Viking Age lineages with multiple gene inactivations. The analysis pushes back the date of the earliest variola infection in humans by ∼1000 years and reveals the existence of a previously unknown virus clade. This is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. |
| Databáze: | OpenAIRE |
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