Elevated IL-13 in effusions of patients with HIV and primary effusion lymphoma as compared with other Kaposi sarcoma herpesvirus-associated disorders
| Autor: | Kathryn Lurain, Matthew Lindsley, Armando C. Filie, Joseph M. Ziegelbauer, Robert Yarchoan, Wendell Miley, Maryalice Stetler-Stevenson, Thomas S. Uldrick, Nazzarena Labo, Hao-Wei Wang, Elena Cornejo-Castro, Vickie Marshall, Denise Whitby, Anaida Widell, Constance M. Yuan, Adam Rupert, Ramya Ramaswami |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty viruses Immunology HIV Infections Gastroenterology Article Virus Pathogenesis 03 medical and health sciences 0302 clinical medicine Interquartile range Lymphoma Primary Effusion Internal medicine Humans Immunology and Allergy Medicine 030212 general & internal medicine Sarcoma Kaposi Retrospective Studies Interleukin-13 business.industry virus diseases Retrospective cohort study Exudates and Transudates biochemical phenomena metabolism and nutrition medicine.disease Lymphoma 030104 developmental biology Infectious Diseases Effusion Herpesvirus 8 Human Primary effusion lymphoma Sarcoma business |
| Zdroj: | AIDS |
| ISSN: | 1473-5571 0269-9370 |
| Popis: | OBJECTIVE To assess the cytokine and viral profiles of effusions and peripheral blood among patients diagnosed with HIV and Kaposi sarcoma herpesvirus [KSHV, also known as human herpesvirus 8 (HHV-8)]-associated conditions. DESIGN Retrospective comparative study evaluating clinicopathologic findings in patients with HIV and KSHV-associated conditions presenting with an effusion between 2010 and 2018. METHODS Paired peripheral blood and effusion samples collected at the time of pathological diagnosis of KSHV-associated conditions [Kaposi sarcoma, KSHV-associated multicentric Castleman disease (KSHV-MCD), primary effusion lymphoma (PEL), or KSHV-associated inflammatory cytokine syndrome (KICS)] were evaluated for disease-specific and compartment-specific (effusion vs. blood) characteristics. We assessed 12 cytokines, KSHV viral DNA (KSHV-VL), and Epstein--Barr virus (EBV) viral DNA (EBV-VL). RESULTS Nine patients had PEL, five patients had KSHV-MCD, and eight patients met criteria for KICS; all but one patient had concurrent Kaposi sarcoma in addition to these conditions. PEL effusions had substantially higher levels of IL-13 (median 16.9 pg/ml; interquartile range 9.7--26.9 pg/ml) compared with KSHV-MCD (median |
| Databáze: | OpenAIRE |
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