Copper salicylate as an anti-inflammatory and analgesic agent in arthritic rats
| Autor: | C.C.A. Bernard, T. Jacka, George Singer |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Male
medicine.drug_class Analgesic Administration Oral Arthritis Inflammation Endogeny Pharmacology General Biochemistry Genetics and Molecular Biology Anti-inflammatory chemistry.chemical_compound parasitic diseases Organometallic Compounds medicine Animals General Pharmacology Toxicology and Pharmaceutics Anti-Inflammatory Agents Non-Steroidal Body Weight General Medicine medicine.disease Arthritis Experimental Salicylates Rats Copper salicylate chemistry Anesthesia Rheumatoid arthritis Hyperalgesia medicine.symptom Copper |
| Zdroj: | Life Sciences. 32:1023-1030 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(83)90934-7 |
| Popis: | Recent research indicates that endogenous copper is involved in anti-inflammatory and tissue repair processes. Of interest also is the analgesic efficacy of Cu complexes, since rheumatoid arthritis and similar inflammatory conditions are extremely painful. In pilot experiments, arthritic rats failed to increase voluntarily their rate of drinking a 5 mg/ml solution of copper salicylate (Cu Sal). The data from the experiment reported here showed that a forced oral dose of Cu Sal calculated at 200 mg/kg body weight significantly reduced sensitivity to mechanical pressure in less than 30 minutes but more than 15 minutes. The analgesic effect of the Cu Sal was greater for arthritic than for non-arthritic rats, suggesting that two types of analgesia are involved. First, it produces a direct analgesic effect which works irrespective of the presence of inflammation. Second, it appears to have an indirect analgesic effect due to reduction of inflammatory hyperalgesia. It was also found that Cu Sal administered orally reduces inflammation in rats with adjuvant arthritis. In summary, the results from this experiment demonstrate that Cu Sal has specific and general analgesic properties and anti-inflammatory potential. |
| Databáze: | OpenAIRE |
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