Fatal myeloencephalopathy due to accidental intrathecal vincristin administration: a report of two cases
| Autor: | F. Driever, O.D. Wiestler, Reinhard Dettmeyer, Burkhard Madea, A. Becker |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Pathology medicine.medical_specialty Vincristine Encephalopathy Pathology and Forensic Medicine Central nervous system disease Fatal Outcome medicine Humans Medication Errors Encephalomyelitis Injections Spinal business.industry Lymphoblastic lymphoma Middle Aged medicine.disease Antineoplastic Agents Phytogenic Leukemia Lymphoid Leukemia Regimen Child Preschool Anesthesia Accidental Toxicity Female business Law medicine.drug |
| Zdroj: | Forensic Science International. 122:60-64 |
| ISSN: | 0379-0738 |
| Popis: | We report on two fatal cases of accidental intrathecal vincristine instillation in a 5-year old girl with recurrent acute lymphoblastic leucemia and a 57-year old man with lymphoblastic lymphoma. The girl died seven days, the man four weeks after intrathecal injection of vincristine. Clinically, the onset was characterized by the signs of opistothonus, sensory and motor dysfunction and ascending paralysis. Histological and immunohistochemical investigations (HE-LFB, CD-68, Neurofilament) revealed degeneration of myelin and axons as well as pseudocystic transformation in areas exposed to vincristine, accompanied by secondary changes with numerous prominent macrophages. The clinical course and histopathological results of the two cases are presented. A review of all reported cases in the literature is given. A better controlled regimen for administering vincristine and intrathecal chemotherapy is recommended. |
| Databáze: | OpenAIRE |
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