Impact of preoperative anxiolytic on surgical site infection in patients undergoing abdominal hysterectomy
| Autor: | Rosa Maria Levandovski, Wolnei Caumo, Maria Beatriz Cardoso Ferreira, Daniel Lemons da Silva, Maria Paz Loayza Hidalgo, Cassio Alves Konrath |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Risk medicine.medical_specialty Epidemiology Visual analogue scale medicine.drug_class Anxiety Hysterectomy Placebo Anxiolytic Postoperative Complications Double-Blind Method Preoperative Care medicine Humans Surgical Wound Infection In patient Pain Measurement Pain Postoperative Diazepam business.industry Incidence Health Policy Public Health Environmental and Occupational Health Analgesia Patient-Controlled Middle Aged Confidence interval Surgery Logistic Models Infectious Diseases Anti-Anxiety Agents Anesthesia Relative risk Female medicine.symptom business medicine.drug |
| Zdroj: | American Journal of Infection Control. 36:718-726 |
| ISSN: | 0196-6553 |
| DOI: | 10.1016/j.ajic.2007.12.010 |
| Popis: | Background An increased anxiety may be associated with a higher risk of surgical site infection (SSI), but there is little objective data on the effect of preoperative anxiolytic interventions on SSI. To address this issue, we evaluated the effects of preoperative diazepam on postoperative SSI following abdominal hysterectomy. Methods This randomized, double-blinded, placebo-controlled study included 130 patients, American Society of Anesthesiologist physical status 1 or 2. Patients were randomly assigned to receive either oral diazepam 10 mg (n = 65) or placebo (n =65) the night before and 1 hour prior to surgery. The assessment instruments were the Visual Analogue Scale and the State-Trait Anxiety Inventory. SSI was diagnosed according to the criteria of the Centers for Disease Control and Prevention with standard follow-up of 30 days. Results The relative risk (RR) was 1.79 (95% confidence interval [CI]: 1.31-2.43), and the number of patients that needed to be treated was 5.2 (95% CI: 2.74-50.76) to prevent 1 additional SSI. The RR for SSI in placebo-treated patients with high postoperative anxiety was 1.65 (95% CI: 1.07-2.56). Conclusion Diazepam-treated patients showed lower postoperative anxiety and lower incidence of SSI up to 30 days after surgery compared with placebo in patients undergoing abdominal hysterectomy. |
| Databáze: | OpenAIRE |
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