Predicting sensorimotor and memory deficits after neonatal ischemic stroke with reperfusion in the rat

Autor: Etienne Jacotot, David Chauvier, Madeleine Bezault, Valentine Bouet, Michel Boulouard, Sylvain Renolleau, Steve Ankri, Thomas Freret, Pascale Schumann-Bard
Přispěvatelé: Groupe Mémoire et Plasticité comportementale (GMPc), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU), CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Department of Reproductive Biology, Imperial College London, Theraptosis Research Laboratory, Theraptosis S.A., Normandie Université (NU), Université de Caen Basse-Normandie, Service de Réanimation Néonatale et Pédiatrique, Université Pierre et Marie Curie - Paris 6 (UPMC) - Assistance publique - Hôpitaux de Paris (AP-HP) - CHU Trousseau [APHP], Université de Caen Basse-Normandie (UNICAEN)
Jazyk: angličtina
Rok vydání: 2010
Předmět:
Male
Statistics as Topic
Ischemia
Posterior parietal cortex
Sensory system
Motor Activity
Somatosensory system
Lesion
03 medical and health sciences
Behavioral Neuroscience
0302 clinical medicine
Double-Blind Method
Predictive Value of Tests
Pregnancy
Glial Fibrillary Acidic Protein
Reflex
medicine
Avoidance Learning
Animals
Antigens
Rats
Wistar
Maze Learning
Stroke
Gait Disorders
Neurologic
030304 developmental biology
0303 health sciences
Analysis of Variance
Memory Disorders
[SCCO.NEUR]Cognitive science/Neuroscience
[SCCO.NEUR] Cognitive science/Neuroscience
Age Factors
Brain
Ectodysplasins
medicine.disease
Motor coordination
Rats
Disease Models
Animal
Gliosis
Animals
Newborn
Ischemic Attack
Transient
Phosphopyruvate Hydratase
Reperfusion
Exploratory Behavior
Female
Proteoglycans
medicine.symptom
Psychology
Neuroscience
030217 neurology & neurosurgery
Zdroj: Behavioural Brain Research
Behavioural Brain Research, Elsevier, 2010, 212 (1), pp.56-63. ⟨10.1016/j.bbr.2010.03.043⟩
Behav Brain Res
Behav Brain Res, 2010, 212 (1), pp.56-63. <10.1016/j.bbr.2010.03.043>
ISSN: 0166-4328
1872-7549
Popis: International audience; Among experimental models of perinatal ischemic stroke, Renolleau's model mimics selected types of stroke at birth, including ischemia and reperfusion. However, its behavioural consequences on development have been poorly described. Here, ischemia-reperfusion was performed in 7-day-old Wistar rats. Between the ages of 9 and 40 days, sensorimotor and memory functions were assessed. The infarcted area was analysed by immunohistochemistry at 40 days of age. The remaining lesion was in the parietal cortex, in the form of a cone-shaped area. This area contained glial cells but neither neurons nor macrophages. Transient focal neonatal ischemia led to sensorimotor alterations in early adulthood, such as postural asymmetry, motor coordination and somatosensory deficits, and hyperactivity, as well as cognitive impairments, such as spatial reference memory deficits. Based on these results, we propose here a selection of behavioural tests that should constitute meaningful tools for assessing sensory and cognitive functions after experimental neonatal ischemic stroke.
Databáze: OpenAIRE
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