Predicting sensorimotor and memory deficits after neonatal ischemic stroke with reperfusion in the rat
Autor: | Etienne Jacotot, David Chauvier, Madeleine Bezault, Valentine Bouet, Michel Boulouard, Sylvain Renolleau, Steve Ankri, Thomas Freret, Pascale Schumann-Bard |
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Přispěvatelé: | Groupe Mémoire et Plasticité comportementale (GMPc), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU), CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Department of Reproductive Biology, Imperial College London, Theraptosis Research Laboratory, Theraptosis S.A., Normandie Université (NU), Université de Caen Basse-Normandie, Service de Réanimation Néonatale et Pédiatrique, Université Pierre et Marie Curie - Paris 6 (UPMC) - Assistance publique - Hôpitaux de Paris (AP-HP) - CHU Trousseau [APHP], Université de Caen Basse-Normandie (UNICAEN) |
Jazyk: | angličtina |
Rok vydání: | 2010 |
Předmět: |
Male
Statistics as Topic Ischemia Posterior parietal cortex Sensory system Motor Activity Somatosensory system Lesion 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Double-Blind Method Predictive Value of Tests Pregnancy Glial Fibrillary Acidic Protein Reflex medicine Avoidance Learning Animals Antigens Rats Wistar Maze Learning Stroke Gait Disorders Neurologic 030304 developmental biology 0303 health sciences Analysis of Variance Memory Disorders [SCCO.NEUR]Cognitive science/Neuroscience [SCCO.NEUR] Cognitive science/Neuroscience Age Factors Brain Ectodysplasins medicine.disease Motor coordination Rats Disease Models Animal Gliosis Animals Newborn Ischemic Attack Transient Phosphopyruvate Hydratase Reperfusion Exploratory Behavior Female Proteoglycans medicine.symptom Psychology Neuroscience 030217 neurology & neurosurgery |
Zdroj: | Behavioural Brain Research Behavioural Brain Research, Elsevier, 2010, 212 (1), pp.56-63. ⟨10.1016/j.bbr.2010.03.043⟩ Behav Brain Res Behav Brain Res, 2010, 212 (1), pp.56-63. <10.1016/j.bbr.2010.03.043> |
ISSN: | 0166-4328 1872-7549 |
Popis: | International audience; Among experimental models of perinatal ischemic stroke, Renolleau's model mimics selected types of stroke at birth, including ischemia and reperfusion. However, its behavioural consequences on development have been poorly described. Here, ischemia-reperfusion was performed in 7-day-old Wistar rats. Between the ages of 9 and 40 days, sensorimotor and memory functions were assessed. The infarcted area was analysed by immunohistochemistry at 40 days of age. The remaining lesion was in the parietal cortex, in the form of a cone-shaped area. This area contained glial cells but neither neurons nor macrophages. Transient focal neonatal ischemia led to sensorimotor alterations in early adulthood, such as postural asymmetry, motor coordination and somatosensory deficits, and hyperactivity, as well as cognitive impairments, such as spatial reference memory deficits. Based on these results, we propose here a selection of behavioural tests that should constitute meaningful tools for assessing sensory and cognitive functions after experimental neonatal ischemic stroke. |
Databáze: | OpenAIRE |
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