Effect of Paraquat-Induced Lung Damage on Permeability of Rat Lung to Drugs
| Autor: | Thomas H. Gardiner, Lewis S. Schanker |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Lung Diseases
Male Paraquat Drug media_common.quotation_subject Procainamide Pharmacology General Biochemistry Genetics and Molecular Biology Single oral dose chemistry.chemical_compound Pulmonary Absorption medicine Animals Lung media_common business.industry Aminohippuric Acids Water Cannula Rats medicine.anatomical_structure chemistry business Procaine amide ethobromide Procaine Amide |
| Zdroj: | Experimental Biology and Medicine. 151:288-292 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-151-39194 |
| Popis: | SummaryTo investigate the effect of paraquat-induced lung damage on pulmonary absorption of drugs, rats were given a single oral dose of paraquat (250 mg/kg), and rates of drug absorption from damaged and control lungs were compared after various times. To measure absorption rates of drugs, 0.1 ml of 10 mM drug solution was administered through a tracheal cannula to anesthetized animals and, after various times, lungs were assayed for unabsorbed compound. Drugs investigated were procaine amide ethobromide, p-aminohippuric acid, and procaine amide. Rates of drug absorption increased 1.4-2.8-fold at 3-5 days after paraquat administration and returned to near control values by the 15th day. The results suggest that paraquat-induced lung damage increases the porosity of the pulmonary epithelium.The authors are indebted to Mrs. Jean C. Henderson for her excellent technical assistance. Appreciation is also extended to Dr. Charles Dunlap and Mrs. Viola Flanagan, Pathology Department, University of Missouri-Kansa... |
| Databáze: | OpenAIRE |
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