External apical root resorption concurrent with orthodontic forces: the genetic influence
| Autor: | Rosa M. Yañez-Vico, Jose Enrique Solano, Nuria Nieto-Nieto |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Tooth Movement Techniques
TaqI Basic science Root Resorption Dentistry Biology Calcitriol receptor Orthodontics Corrective 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Genetic variation Genetic predisposition Humans Genetic Predisposition to Disease General Dentistry Pathological business.industry Genetic Variation 030206 dentistry General Medicine chemistry IL1A 030220 oncology & carcinogenesis Etiology business |
| Zdroj: | Acta Odontologica Scandinavica. 75:280-287 |
| ISSN: | 1502-3850 0001-6357 |
| DOI: | 10.1080/00016357.2017.1294260 |
| Popis: | Root resorption is a pathological process of multifactorial origin related to the permanent loss of dental root structure in response to a mechanical, inflammatory, autoimmune or infectious stimulus. External apical root resorption (EARR) is a frequent clinical complication secondary to orthodontic tooth movement; apart from variables related to treatment, environmental factors and/or interindividual genetic variations can confer susceptibility or resistance to its occurrence. In this context, genetic predisposition has been described as an etiological factor, together with mechanical factors derived from orthodontic treatment. In recent years, international research groups have determined the degree of influence of some genetic biomarkers in defining increased/reduced susceptibility to postorthodontic EARR. The influences of the IL1 gene cluster (IL1B, IL1A, IL1RN, IL6), P2RX7, CASP1, OPG (TNFRSF11B), RANK (TNFRSF11A), Osteopontin (OPN), TNFα, the vitamin D receptor (TaqI), TNSALP and IRAK1 have been analyzed. The objective of the present review study was to compile and analyze the latest information about the genetic background predisposing to EARR during orthodontic treatment. Genetics-based studies along with other basic science research in the field might help to clarify the exact nature of EARR, the influence of genetic inheritance and possibly lead to the prevention or even eradication of this phenomenon during orthodontic treatment. |
| Databáze: | OpenAIRE |
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