Potassium canrenoate in the treatment of long-term digoxin-induced arrhythmias in conscious dogs
| Autor: | Billy K. Yeh, Norberto T. deGuzman |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Male
Inotrope Bundle of His Digoxin medicine.medical_specialty Sinoatrial block Heart Ventricles Sinus bradycardia Potassium medicine.medical_treatment chemistry.chemical_element Potassium Chloride Electrocardiography Dogs Pregnadienes Tachycardia Internal medicine Bradycardia medicine Animals Arrhythmia Sinus cardiovascular diseases Diuretics Normal Sinus Rhythm Mineralocorticoid Receptor Antagonists business.industry Sodium Arrhythmias Cardiac Ketosteroids medicine.disease Heart Block chemistry Anesthesia Potassium canrenoate Atrioventricular Node cardiovascular system Cardiology Female medicine.symptom Diuretic Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | The American Journal of Cardiology. 35:413-420 |
| ISSN: | 0002-9149 |
| Popis: | The effects of potassium canrenoate on arrhythmias induced by long-term progressive digoxin toxicity were studied in eight conscious beagle dogs. Sinus bradycardia and sinoatrial block, as well as atrioventricular (A-V) conduction disturbances, were consistently alleviated by administration of potassium canrenoate. Premature supraventricular (including junctional) and ventricular depolarizations as well as ventricular tachycardias were also suppressed. Although potassium canrenoate always terminated the digitalis-induced arrhythmias, it usually converted the rhythm to sinus arrhythmia rather than to normal sinus rhythm. Equimolar sodium canrenoate, but not potassium chloride, had similar reversal effects on arrhythmias induced by long-term digoxin intoxication. These data indicate that canrenoate, a diuretic agent with reported positive inotropic effects, may be useful in the treatment of digitalis-induced arrhythmias in man. |
| Databáze: | OpenAIRE |
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