Prognostic significance of bone morphogenetic protein 6 (BMP6) expression, clinical and pathological factors in clinically node-negative oral squamous cell carcinoma (OSCC)

Autor: Igor Erjavec, Ante Bolanca, Spomenka Manojlović, Mladen Petrovečki, Ivica Lukšić, Petar Suton, Lovorka Grgurevic, Danko Müller, Iva Nikles, Stjepan Dokuzovic, Slobodan Vukicevic
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
Oncology
BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences
Mouth Neoplasms / metabolism
Survival
Bone Morphogenetic Protein 6
Bone morphogenetic protein 6
Disease
Cohort Studies
0302 clinical medicine
Recurrence
Carcinoma
Squamous Cell / pathology
Neoplasm Metastasis
Aged
80 and over
Incidence (epidemiology)
Oral cancer
BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti
Mouth Neoplasms / pathology
Occult neck metastases
Middle Aged
Bone Morphogenetic Protein 6 / metabolism
Prognosis
Immunohistochemistry
Head and Neck Neoplasms
030220 oncology & carcinogenesis
Cohort
Carcinoma
Squamous Cell
Keratins
Mouth Neoplasms
Female
Oral Surgery
Positive Surgical Margin
BIOMEDICINA I ZDRAVSTVO. Temeljne medicinske znanosti
Cohort study
Adult
Carcinoma
Squamous Cell / metabolism
Neoplasm Recurrence
Local / metabolism
medicine.medical_specialty
03 medical and health sciences
Internal medicine
medicine
Humans
Pathological
Aged
business.industry
BIOMEDICINE AND HEALTHCARE. Basic Medical Sciences
Neoplasm Recurrence
Local / pathology
030206 dentistry
bone morphogenetic protein 6
occult neck metastases
oral cancer
recurrence
survival
stomatognathic diseases
Otorhinolaryngology
Multivariate Analysis
Keratins / physiology
Surgery
Neoplasm Recurrence
Local
business
Zdroj: Journal of Cranio-Maxillofacial Surgery
Volume 47
Issue 1
ISSN: 1010-5182
Popis: Bone morphogenetic protein 6 (BMP6) has unique properties regarding structure and function in supporting bone formation during development and adult life. Despite its known role in various malignant tumors, the prognostic significance of BMP6 expression in oral squamous cell carcinoma (OSCC) remains unknown. The aim of the study was to investigate immunohistochemical expression of BMP6 in OSCC in correlation with clinical and pathological parameters, disease recurrence and survival. In addition, we investigated other parameters in order to identify prognosticators of neck metastases and final outcome. The study included 120 patients with clinically T1-3N0 OSCC who were primarily surgically treated between 2003 and 2008. There were 99 (82.5%) male and 21 (17.5%) female patients. The five-year disease- specific survival for the whole cohort was 79.7%. Tumors smaller than 2 cm in diameter showed higher incidence of strong BMP6 expression. No statistical correlation was observed between other clinico- pathological factors and BMP6 expression. Expression of BMP6 was not associated with disease recurrence and survival. BMP6 may not serve as prognosticator of final outcome or recurrence in clinically node-negative OSCC subjects. In multivariate analysis predictors of poorer survival were positive surgical margin, moderate tumor cell differentiation and pathological involvement of levels IV and/or V.
Databáze: OpenAIRE
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