Significant circulation of influenza B viruses mismatching the recommended vaccine-lineage in South Korea, 2007–2014

Autor: Hee Jin Cheong, Jin Soo Lee, Sun Hee Lee, Woo Joo Kim, Yu Bin Seo, Joon Young Song, Jung Yeon Heo, Hye Won Jeong, Chae Seung Lim, Dong Hyun Kim, Jung Hwa Lee, Kyung-Hwa Park, Won Suk Choi, Han Sol Lee, Seong Heon Wie, Sung Il Woo, Sooyeon Lim, Kyung Soon Cho, Jacob Lee, Ji Yun Noh, Young Keun Kim, Shin Woo Kim
Rok vydání: 2018
Předmět:
Zdroj: Vaccine. 36:5304-5308
ISSN: 0264-410X
DOI: 10.1016/j.vaccine.2018.07.021
Popis: We aimed to characterize the lineages of influenza B viruses obtained from clinical specimens during the 2007-2014 seasons in South Korea. RT-PCR for the partial hemagglutinin gene of influenza B virus was performed on laboratory-confirmed influenza B samples from the 2007-2008 season to 2013-2014 season. A phylogenetic tree was generated, and current influenza vaccine strains for the Northern Hemisphere were used as representative strains of Victoria and Yamagata lineages. A total of 571 influenza B virus sequences were analyzed. During the 2009-2010 season, most of the circulating influenza B viruses matched the vaccine strain; 91.0% (91/100) of viruses belonged to the Victoria lineage. In the 2007-2008, 2011-2012, and 2013-2014 seasons, co-circulation of each influenza B lineage was found with a match ratio to the vaccine strain of 53.2% (42/79), 40.9% (63/154), and 58.3% (134/230), respectively. Overall, 41.7% (238/571) of the circulating influenza B viruses belonged to the lineage mismatching the vaccine strain. During the seven influenza seasons, influenza B epidemics were substantial in four seasons in South Korea. Significant mismatches of the vaccine and lineage of the circulating influenza B viruses were found. The current trivalent influenza vaccine may not be fully suitable for effective protection against influenza B.
Databáze: OpenAIRE
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