How the Midbrain Helps Us Decide
| Autor: | Vincent B. McGinty |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Neurons
0301 basic medicine Superior Colliculi Computer science business.industry General Neuroscience Superior colliculus Decision Making Decision bias Neurophysiology Article Midbrain 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Text mining nervous system Encoding (memory) Detection theory sense organs skin and connective tissue diseases business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neuron |
| ISSN: | 0896-6273 |
| Popis: | Simple decisions arise from the evaluation of sensory evidence. But decisions are determined by more than just evidence. Individuals establish internal, decision criteria that influence how they respond. Where or how decision criteria are established in the brain remains poorly understood. Here, we show that neuronal activity in the superior colliculus (SC) predicts changes in decision criteria. Using a novel ‘Yes-No’ task that isolates changes in decision criterion from changes in decision sensitivity, and computing neuronal measures of sensitivity and criterion, we find that SC neuronal activity correlates with the decision criterion regardless of the location of the choice report. We also show that electrical manipulation of activity within the SC produces changes in decisions consistent with changes in decision criteria and are largely independent of the choice report location. Our correlational and causal results together provide strong evidence that SC activity signals the position of a decision criterion. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|