Mutation rate dynamics reflect ecological change in an emerging zoonotic pathogen

Autor: Josephine Herbert, A. S. Md. Mukarram Hossain, Gemma G. R. Murray, Marta Matuszewska, Lucy A. Weinert, Alexander W. Tucker, Andrew J. Balmer, Marcelo Gottschalk, Sebastian Bruchmann, Nazreen F. Hadjirin, Caroline L. Kemp, Eric L. Miller
Přispěvatelé: Murray, Gemma G. R. [0000-0002-9531-1711], Balmer, Andrew J. [0000-0001-7446-3428], Herbert, Josephine [0000-0002-8352-6344], Kemp, Caroline L. [0000-0002-0015-3678], Matuszewska, Marta [0000-0002-2653-7725], Bruchmann, Sebastian [0000-0001-8721-5386], Hossain, A. S. Md. Mukarram [0000-0003-2654-8982], Gottschalk, Marcelo [0000-0002-2196-2212], Tucker, Alexander W. [0000-0003-0062-0843], Miller, Eric [0000-0002-7157-6213], Weinert, Lucy A. [0000-0002-9279-6012], Apollo - University of Cambridge Repository, Murray, Gemma [0000-0002-9531-1711], Balmer, Andrew [0000-0001-7446-3428], Tucker, Alexander [0000-0003-0062-0843], Weinert, Lucy [0000-0002-9279-6012]
Rok vydání: 2021
Předmět:
Cancer Research
Mutation rate
Streptococcus suis
Swine
Adaptation
Biological
QH426-470
Pathology and Laboratory Medicine
Genome
Communicable Diseases
Emerging
0302 clinical medicine
Medical Conditions
Mutation Rate
Zoonoses
Mobile Genetic Elements
Genetics (clinical)
Mammals
0303 health sciences
Bacterial Genomics
Ecology
Virulence
Microbial Genetics
Eukaryota
Genomics
Bacterial Pathogens
Deletion Mutation
Infectious Diseases
Medical Microbiology
Vertebrates
Pathogens
Research Article
Microbial Genomics
Biology
Microbiology
03 medical and health sciences
Genetic Elements
Streptococcal Infections
Genetics
Bacterial Genetics
Animals
Evolutionary dynamics
Molecular Biology
Genome size
Microbial Pathogens
Ecology
Evolution
Behavior and Systematics
030304 developmental biology
Medicine and health sciences
Biology and life sciences
Organisms
Bacteriology
Mutation Accumulation
biology.organism_classification
FOS: Biological sciences
Mutation
Amniotes
Mobile genetic elements
Zoology
030217 neurology & neurosurgery
Zdroj: PLoS Genetics, Vol 17, Iss 11 (2021)
PLoS Genetics, Vol 17, Iss 11, p e1009864 (2021)
PLoS Genetics
Popis: Funder: Isaac Newton Trust; funder-id: http://dx.doi.org/10.13039/501100004815
Funder: Newnham College, University of Cambridge; funder-id: http://dx.doi.org/10.13039/501100000663
Funder: Biotechnology and Biological Sciences Research Council; funder-id: http://dx.doi.org/10.13039/501100000268
Funder: Medical Research Council; funder-id: http://dx.doi.org/10.13039/501100000265
Funder: Raymond and Beverly Sackler Foundation; funder-id: http://dx.doi.org/10.13039/100013112
Mutation rates vary both within and between bacterial species, and understanding what drives this variation is essential for understanding the evolutionary dynamics of bacterial populations. In this study, we investigate two factors that are predicted to influence the mutation rate: ecology and genome size. We conducted mutation accumulation experiments on eight strains of the emerging zoonotic pathogen Streptococcus suis. Natural variation within this species allows us to compare tonsil carriage and invasive disease isolates, from both more and less pathogenic populations, with a wide range of genome sizes. We find that invasive disease isolates have repeatedly evolved mutation rates that are higher than those of closely related carriage isolates, regardless of variation in genome size. Independent of this variation in overall rate, we also observe a stronger bias towards G/C to A/T mutations in isolates from more pathogenic populations, whose genomes tend to be smaller and more AT-rich. Our results suggest that ecology is a stronger correlate of mutation rate than genome size over these timescales, and that transitions to invasive disease are consistently accompanied by rapid increases in mutation rate. These results shed light on the impact that ecology can have on the adaptive potential of bacterial pathogens.
Databáze: OpenAIRE
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