Potential celiac disease in type 1 diabetes: a multicenter study
| Autor: | Franzese, A., Iafusco, D., Spadaro, R., Cavaliere, O., Prisco, F., Auricchio, R., Troncone, R., Valerio, G., Lera, R., Fontana, F., Cherubini, V., Biagioni, M., Pasquino, B., Gallo, F., Suprani, T., Tumini, S., Lazzaro, N., Toni, S., D'Annunzio, G., Emmanuele, V., Bruzzese, M., Lombardo, F., Bonfanti, R., Tronconi, G. M., Iughetti, L., Monciotti, C., Cardella, F., Chiari, G., Vanelli, M., Calcaterra, V., Federico, G., Crino, A., Cappa, M., Patera, I., Negro, I., Delvecchio, M., Rabbone, I., Guerraggio, L., Salvatoni, A., Costantini, C., Pinelli, L. |
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| Přispěvatelé: | Franzese, A, Iafusco, D, Spadaro, R, Cavaliere, O, Prisco, F, Auricchio, R, Troncone, R, Valerio, G, Bonfanti, R, Study Group on diabetes of Italian Society of pediatric Endocrinology and, Diabetology, Franzese, Adriana, D., Iafusco, R., Spadaro, O., Cavaliere, F., Prisco, Auricchio, Renata, Troncone, Riccardo, G., Valerio, S. o., Diabete, Diabetology, Iafusco, Dario, THE STUDY GROUP ON DIABETES OF ITALIAN SOCIETY OF, Pediatric, ENDOCRINOLOGY AND DIABETOLOGY, Isped |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Adolescent endocrine system diseases Endocrinology Diabetes and Metabolism Disease Adolescent Celiac Disease Serology Diet Gluten-Free Endocrinology Internal medicine Diabetes mellitus Internal Medicine medicine Humans Child Type 1 diabetes complications/epidemiology Diet Routine screening business.industry epidemiology/etiology Child Child Infant nutritional and metabolic diseases Potential celiac disease General Medicine Autoimmune disorders medicine.disease Preschool Cross-Sectional Studies Diabetes Mellitu Celiac disease humanities Gluten-Free Female Humans Infant Male Celiac Disease Child Preschool Cross-Sectional Studies Diabetes Mellitus Type 1 Female Multicenter study Immunology Gluten free business Type 1 |
| Popis: | Aims To describe the prevalence of potential celiac disease (pot-CD) in young patients with type 1 diabetes mellitus (T1DM) and characterize their clinical features. Methods This cross-sectional multicenter study involved 8717 T1DM patients from 31 Italian centers. Information was collected on the total number of T1DM patients, CD patients and pot-CD patients. The following data were collected on pot-CD patients: gender, age at T1DM diagnosis, age at the first CD serological positivity, presence of CD-related symptoms, presence of other autoimmune disorders and treatment with gluten free diet (GFD). One thousand-three-hundred-sixty-one patients who were positive for CD serology were the control group. Results CD serological positivity was found in 7.2% T1DM patients. Prevalence of pot-CD was 12.2% ( n =77) among CD positive patients: symptoms were present in 12/77; a third autoimmune disorder was found in 15 patients. Prevalence of pot-CD in the control population was 8.4% ( n =114; p =0.005). No difference was found with regard to clinical features. Only few symptomatic patients were on GFD both in T1DM and control patients. Conclusions A higher prevalence of pot-CD was found in T1DM patients, that may be ascribed to the routine screening, although the influence of genetic factors cannot be excluded. |
| Databáze: | OpenAIRE |
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