Development of oral cancer tissue-mimicking phantom based on polyvinyl chloride plastisol and graphite for terahertz frequencies
| Autor: | Anna V. Kuzikova, Alexey Popov, Petr Demchenko, Roman Grigorev, Victoria Y. Soboleva, Tianmiao Zhang, Dmitrii V. Zykov, Ravshanjon Nazarov, Mikhail Khodzitskiy, Alexander Bykov, Igor Meglinski |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Paper
Materials science Terahertz radiation optical property Biomedical Engineering 01 natural sciences Imaging phantom 010309 optics Biomaterials terahertz chemistry.chemical_compound SDG 3 - Good Health and Well-being Plastisol effective medium theory 0103 physical sciences Humans cancer Graphite Special Series on Advances in Terahertz Biomedical Science and Applications Polyvinyl Chloride Spectroscopy Phantoms Imaging phantom equipment and supplies Atomic and Molecular Physics and Optics Electronic Optical and Magnetic Materials Refractometry Polyvinyl chloride chemistry Attenuation coefficient oral tissue Mouth Neoplasms Refractive index Biomedical engineering |
| Zdroj: | Zhang, T, Nazarov, R, Popov, A P, Demchenko, P S, Bykov, A V, Grigorev, R O, Kuzikova, A V, Soboleva, V Y, Zykov, D V, Meglinski, I V & Khodzitskiy, M K 2020, ' Development of oral cancer tissue-mimicking phantom based on polyvinyl chloride plastisol and graphite for terahertz frequencies ', Journal of Biomedical Optics, vol. 25, no. 12, 123002 . https://doi.org/10.1117/1.JBO.25.12.123002 Journal of Biomedical Optics |
| DOI: | 10.1117/1.JBO.25.12.123002 |
| Popis: | Significance: A new concept of a biotissue phantom for terahertz (THz) biomedical applications is needed for reliable and long-term usage. Aim: We aimed to develop a new type of biotissue phantom without water content and with controllable THz optical properties by applying graphite powders into a polyvinyl chloride plastisol (PVCP) matrix and to give a numerical description to the THz optical properties of the phantoms using the Bruggeman model (BM) of the effective medium theory (EMT). Approach: The THz optical properties of graphite and the PVCP matrix were measured using THz time-domain spectroscopy, which works in the frequency range from 0.1 to 1 THz. Two phantoms with 10% and 12.5% graphite were fabricated to evaluate the feasibility of describing phantoms using the EMT. The EMT then was used to determine the concentration of graphite required to mimic the THz optical properties of human cancerous and healthy oral tissue. Results: The phantom with 16.7% of graphite has the similar THz optical properties as human cancerous oral tissue in the frequency range of 0.2 to 0.7 THz. The THz optical properties of the phantom with 21.9% of graphite are close to those of human healthy oral tissue in the bandwidth from 0.6 to 0.8 THz. Both the refractive index and absorption coefficient of the samples increase with an increase of graphite concentration. The BM of the EMT was used as the numerical model to describe the THz optical properties of the phantoms. The relative error of the BM for the refractive index estimation and the absorption coefficient is up to 4% and 8%, respectively. Conclusions: A water-free biotissue phantom that mimics the THz optical properties of human cancerous oral tissue was developed. With 21.9% of graphite, the phantom also mimics human healthy oral tissue in a narrow frequency range. The BM proved to be a suitable numerical model of the phantom. |
| Databáze: | OpenAIRE |
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