Transdermal permeation of trimetazidine from nerodilol-based HPMC gel drug reservoir system across rat epidermis
| Autor: | S.M. Al-Saidan, Yellela S.R. Krishnaiah |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Skin Absorption
Vasodilator Agents Trimetazidine Lactose Pharmacology In Vitro Techniques Methylcellulose Administration Cutaneous Drug Delivery Systems medicine Animals Transdermal Dose-Response Relationship Drug business.industry Terpenes technology industry and agriculture General Medicine Penetration (firestop) Transdermal permeation Rats body regions Drug reservoir Hydroxypropylmethyl cellulose Models Animal business Gels medicine.drug |
| Zdroj: | Medical principles and practice : international journal of the Kuwait University, Health Science Centre. 17(1) |
| ISSN: | 1423-0151 |
| Popis: | Objective: To study the in vitro transdermal permeation of trimetazidine from hydroxypropylmethyl cellulose (HPMC) gel drug reservoir system using nerodilol as a penetration enhancer. Materials and Methods: An HPMC gel containing selected concentrations of nerodilol (0, 2, 4 or 5% w/v) and 2.5% w/v of trimetazidine was prepared, and subjected to in vitro permeation studies across rat epidermis. The amount of trimetazidine permeated at different time intervals (1, 2, 4, 8, 12, 18 and 24 h) was estimated, and the data were analyzed to calculate various permeation parameters. Results: There was an increase in the amount of trimetazidine (8,719.7 ± 153.3 µg/cm2)permeated across the rat epidermis up to 24 h (Q24) with an increase in nerodilol concentration (5% w/v) in HPMC gel drug reservoir. However, no significant difference (p > 0.05) was observed in the amount of drug permeated (Q24) with 5% w/v of nerodilol when compared to that obtained with 4% w/v of nerodilol (8,484.5 ± 165.8 µg/cm2). Nerodilol, at a concentration of 4% w/v enhanced the flux of trimetazidine across rat epidermis by about 1.96 times when compared to control. Conclusion: The HPMC gel drug reservoir containing 4% w/v of nerodilol showed optimal transdermal permeation of trimetazidine. |
| Databáze: | OpenAIRE |
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