Relationship between monocyte-to-lymphocyte ratio and coronary plaque vulnerability in patients with stable angina
| Autor: | Hanhua Ji, Xinwen Jian, Zeyuan Fan, Yang Li, Li Li, Tao Liu |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Necrotic core Lymphocyte Clinical Biochemistry Lumen (anatomy) chemical and pharmacologic phenomena Coronary Artery Disease 030204 cardiovascular system & hematology Stable angina Monocytes 03 medical and health sciences 0302 clinical medicine Internal medicine Drug Discovery medicine Humans In patient Angina Stable Lymphocyte Count Lymphocytes 030212 general & internal medicine Risk factor Aged business.industry Monocyte fungi Biochemistry (medical) hemic and immune systems Middle Aged medicine.disease Plaque Atherosclerotic Atheroma medicine.anatomical_structure Cardiology Female business Biomarkers |
| Zdroj: | Biomarkers in Medicine. 11:979-990 |
| ISSN: | 1752-0371 1752-0363 |
| DOI: | 10.2217/bmm-2017-0235 |
| Popis: | Aim: To investigate the relationship between monocyte-to-lymphocyte ratio (MLR) and plaque vulnerability assessed by virtual histology intravascular ultrasound in patients with stable angina. Methods: 133 patients with stable angina were enrolled. Results: MLR was found to be an independent risk factor of thin cap fibrous atheroma (OR: 2.61; p = 0.025). MLR could differentiate thin cap fibrous atheroma with a sensitivity of 73.7% and a specificity of 61.8%. MLR level was positively correlated with the percentage of necrotic core (NC) area at the sites of minimum lumen area and the largest NC area, and positively related to the percentage of NC volume. Conclusion: Circulating MLR level has potential in identifying the vulnerable plaques in the setting of stable angina. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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