Inhibition of inflammatory cell infiltration by bicyclic imidazoles, SK&F 86002 and SK&F 104493
| Autor: | Don E. Griswold, L. M. Hillegass, P. J. Marshall, Paul Elliot Bender, E. F. Webb, Sylvia T. Hoffstein, Nabil Hanna |
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| Rok vydání: | 1989 |
| Předmět: |
Male
Neutrophils Pyridines Leukotriene B4 Immunology Peritonitis Phenidone Dinoprostone Mice Lipoxygenase chemistry.chemical_compound In vivo medicine Animals Edema Immunology and Allergy Ear Diseases Cyclophosphamide Inflammation Mice Inbred BALB C biology Eicosanoid metabolism Anti-Inflammatory Agents Non-Steroidal Imidazoles medicine.disease Molecular biology Chemotaxis Leukocyte Thiazoles Mechanism of action chemistry Biochemistry biology.protein Eicosanoids Arachidonic acid medicine.symptom Infiltration (medical) |
| Zdroj: | Inflammation. 13:727-739 |
| ISSN: | 1573-2576 0360-3997 |
| DOI: | 10.1007/bf00914315 |
| Popis: | The mode of action of the dual inhibitors of eicosanoid metabolism, SK&F 86002 and SK&F 104493 was evaluated on inflammatory cell infiltration induced in mice by carrageenan, monosodium urate crystals, and arachidonic acid. The results were compared to those seen with standard antiinflammatory compounds. Inflammatory cell infiltration was inhibited by SK&F 86002, SK&F 104493, colchicine, and phenidone but not naproxen. In vivo, PMN infiltration induced by LTB4 was inhibited by colchicine but not by SK&F 86002, SK&F 104493, or phenidone treatment. Similarly, in vitro chemotaxis to LTB4 was not inhibited by SK&F 86002. The 5-lipoxygenase inhibitors, SK&F 86002, SK&F 104493, and phenidone inhibited LTB4 production in vivo as well as inflammatory cell infiltration induced by arachidonic acid. The data are consistent with the suggestion that the bicyclic imidazoles inhibit PMN infiltration by virtue of inhibition of LTB4 production. |
| Databáze: | OpenAIRE |
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