Association of mesangial IgM with IgM deposits in the macula densa: an indication of non-specific macromolecule transport rather than immune reactant?
| Autor: | E. Mary Thompson, David J. Evans |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
Pathology Macromolecular Substances Immunoenzyme Techniques Immune system Non specific Internal medicine Biopsy medicine Humans Distal convoluted tubule Transplantation Kidney Mesangial cell medicine.diagnostic_test urogenital system business.industry Biological Transport eye diseases Juxtaglomerular Apparatus Glomerular Mesangium medicine.anatomical_structure Endocrinology Immunoglobulin M Nephrology Macula densa Immunohistochemistry business |
| Zdroj: | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 16(9) |
| ISSN: | 0931-0509 |
| Popis: | Background We observed IgM deposits in the macula densa of the distal convoluted tubule in some renal biopsies with mesangial IgM deposits and did a systematic study to investigate the frequency of this phenomenon. We compared the findings with those in IgA disease. Methods A total of 30 renal biopsies with either isolated predominantly mesangial IgM, or mesangial IgA (+/-IgM) deposition, were retrieved from the files and reviewed independently by both authors. Results Eight showed strong macula densa IgM deposits and another three showed weak deposits in the macula densa on immunoperoxidase staining. A total of 14 biopsies also showed mesangial IgA deposition but IgA was not seen in the macula densa. Conclusions These results confirm the association of IgM deposits in the macula densa with mesangial IgM, and suggest that mesangial IgM deposits may be a reflection of non-specific macromolecule transport rather than an immune reactant. |
| Databáze: | OpenAIRE |
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