Molecular specializations of deep cortical layer analogs in songbirds
| Autor: | Alexander A. Nevue, Claudio V. Mello, Morgan Wirthlin, Peter V. Lovell |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Arcopallium media_common.quotation_subject lcsh:Medicine In situ hybridization Biology Molecular neuroscience Article 03 medical and health sciences Sensorimotor processing 0302 clinical medicine Motor control medicine Animals lcsh:Science Zebra finch In Situ Hybridization LINGO1 media_common Motor theory of speech perception Multidisciplinary Behavior Animal Gene Expression Profiling lcsh:R Motor Cortex 030104 developmental biology medicine.anatomical_structure Female Vocal learning lcsh:Q Finches Vocalization Animal Imitation Neuroscience 030217 neurology & neurosurgery Motor cortex |
| Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020) Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-020-75773-4 |
| Popis: | How the evolution of complex behavioral traits is associated with the emergence of novel brain pathways is largely unknown. Songbirds, like humans, learn vocalizations via tutor imitation and possess a specialized brain circuitry to support this behavior. In a comprehensive in situ hybridization effort, we show that the zebra finch vocal robust nucleus of the arcopallium (RA) shares numerous markers (e.g. SNCA, PVALB) with the adjacent dorsal intermediate arcopallium (AId), an avian analog of mammalian deep cortical layers with involvement in motor function. We also identify markers truly unique to RA and thus likely linked to modulation of vocal motor function (e.g. KCNC1, GABRE), including a subset of the known shared markers between RA and human laryngeal motor cortex (e.g. SLIT1, RTN4R, LINGO1, PLXNC1). The data provide novel insights into molecular features unique to vocal learning circuits, and lend support for the motor theory for vocal learning origin. |
| Databáze: | OpenAIRE |
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