Relationship of interleukin-4 to isotypic distribution of anti-double-stranded DNA antibodies in systemic lupus erythematosus
| Autor: | A. Lamour, Dominique Mottier, C. Jorgensen, Loïc Guillevin, C. Series, David A. Isenberg, Dueymes Jm, Jean Jouquan, Alexandros A. Drosos, Pierre Youinou, B. Grobois, Haralampos M. Moutsopoulos, Cl. Conri, C. Massot, P. Philippe, Maryvonne Dueymes, Pierre-Yves Hatron, O. Meyer, J. Barrier, Y Shoenfeld, P. Galanaud, Jean-Charles Piette, Jacques Sany, J. Cledes, R. Maran, G. Dien, J.F. Besancenot, P. Le Goff, M. Longy-Boursier |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
Male Systemic disease Anti-nuclear antibody Adolescent Immunology immune system diseases medicine Immunology and Allergy Humans Lupus Erythematosus Systemic skin and connective tissue diseases Interleukin 4 Aged Aged 80 and over Lupus erythematosus biology Autoantibody General Medicine DNA Middle Aged medicine.disease Isotype Immunoglobulin Isotypes Antibodies Antinuclear biology.protein Female Interleukin-4 Antibody Anti-SSA/Ro autoantibodies |
| Zdroj: | International archives of allergy and immunology. 101(4) |
| ISSN: | 1018-2438 |
| Popis: | IgG subclasses of anti-double-stranded DNA antibodies were determined in 182 patients with systemic lupus erythematosus. All isotypes were detected, but IgG1 and IgG3 were predominant (62 and 51% of the cases, respectively). An average of 64 +/- 27% was IgG1, 16 +/- 22% IgG2, 16 +/- 19% IgG3 and 4 +/- 10% IgG4. The rank order or frequency was IgG1, IgG3, IgG2 and IgG4 in patients with musculoskeletal involvement; IgG1, IgG2, IgG3 and IgG4 in those with renal complications; IgG3, IgG1, IgG2 and IgG4 in those with cutaneous involvement; and IgG1, IgG3, IgG2 and IgG4 in those with hematological manifestations. Interleukin-4 (IL-4) was detectable in 17 of 36 selected patients, as opposed to 1 of 40 normal controls. The percentage of the total autoantibody contributed by IgG1 was significantly higher (p0.03) in these patients than in the remainder with undetectable levels of IL-4. |
| Databáze: | OpenAIRE |
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