Melanoma, thyroid cancer, and gynecologic cancers in a cohort of female flight attendants
| Autor: | Mark P. Little, Mary K. Schubauer-Berigan, Misty J. Hein, Alice J. Sigurdson, Jeri L. Anderson, Annette L. Christianson, Lynne E. Pinkerton |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Oncology medicine.medical_specialty Skin Neoplasms Genital Neoplasms Female Population Uterine Cervical Neoplasms Chronobiology Disorders 03 medical and health sciences 0302 clinical medicine Risk Factors Uterine cancer Occupational Exposure Internal medicine Humans Medicine Life Tables Thyroid Neoplasms education Melanoma Thyroid cancer Ovarian Neoplasms Cervical cancer education.field_of_study business.industry Incidence Incidence (epidemiology) Thyroid Public Health Environmental and Occupational Health Cancer Middle Aged medicine.disease 030210 environmental & occupational health United States Circadian Rhythm medicine.anatomical_structure 030220 oncology & carcinogenesis Uterine Neoplasms Cohort Aerospace Medicine Female business Cosmic Radiation |
| Zdroj: | American Journal of Industrial Medicine. 61:572-581 |
| ISSN: | 0271-3586 |
| Popis: | BACKGROUND Flight attendants may have an increased risk of some cancers from occupational exposure to cosmic radiation and circadian disruption. METHODS The incidence of thyroid, ovarian, and uterine cancer among ∼6000 female flight attendants compared to the US population was evaluated via life table analyses. Associations of these cancers, melanoma, and cervical cancer with cumulative cosmic radiation dose and metrics of circadian disruption were evaluated using Cox regression. RESULTS Incidence of thyroid, ovarian, and uterine cancer was not elevated. No significant, positive exposure-response relations were observed. Weak, non-significant, positive relations were observed for thyroid cancer with cosmic radiation and time zones crossed and for melanoma with another metric of circadian disruption. CONCLUSIONS We found little evidence of increased risk of these cancers from occupational cosmic radiation or circadian disruption in female flight attendants. Limitations include few observed cases of some cancers, limited data on risk factors, and misclassification of exposures. |
| Databáze: | OpenAIRE |
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