Effect of Melatonin Supplementation on Antioxidant Status and DNA Damage in High Intensity Trained Athletes
| Autor: | Manuel Ortiz-Franco, Jorge Molina-López, Iryna Rusanova, Bartholomé Quintero, Germaine Escames, Elena Planells, Darío Acuña-Castroviejo |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Antioxidant DNA damage medicine.medical_treatment Physical Therapy Sports Therapy and Rehabilitation High-Intensity Interval Training medicine.disease_cause Antioxidants Superoxide dismutase Melatonin Young Adult 03 medical and health sciences 0302 clinical medicine Double-Blind Method Internal medicine medicine Humans Orthopedics and Sports Medicine Lymphocytes chemistry.chemical_classification Glutathione Peroxidase biology Superoxide Dismutase Glutathione peroxidase 030229 sport sciences Comet assay Oxidative Stress Endocrinology chemistry Athletes Dietary Supplements Immunology biology.protein High-intensity interval training 030217 neurology & neurosurgery Oxidative stress DNA Damage medicine.drug |
| Zdroj: | International Journal of Sports Medicine. 38:1117-1125 |
| ISSN: | 1439-3964 0172-4622 |
| DOI: | 10.1055/s-0043-119881 |
| Popis: | The aim of the study was to evaluate the effect of melatonin supplementation on antioxidant capacity and DNA damage in high intensity interval training (HIIT) athletes. A 2-week randomised, double-blinded, placebo-controlled trial with two groups was conducted. Placebo (PG) and melatonin (MG) (20 mg/d) athletes were monitored over a two-week period of HIIT and strength training. The total antioxidant capacity (TAC) and the glutathione peroxidase (GPx) and superoxide dismutase (SOD) activities were analysed in blood samples. DNA damage was measured in isolated lymphocytes by comet assay prior to and immediately after exercise. The supplementation increased plasma melatonin levels in the melatonin-treated group (p |
| Databáze: | OpenAIRE |
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