Combating Obesity With Thermogenic Fat: Current Challenges and Advancements
| Autor: | Ruping Pan, Pema Maretich, Xiaohua Zhu, Yong Chen |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cold stimulation UCP1 Mini Review Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Adrenergic beta-3 Receptor Agonists White adipose tissue Disease Bioinformatics lcsh:Diseases of the endocrine glands. Clinical endocrinology 03 medical and health sciences 0302 clinical medicine Endocrinology Adipose Tissue Brown β adrenergic signaling Adrenergic signaling β-adrenergic signaling Medicine Animals Humans Obesity glycolytic beige fat lcsh:RC648-665 business.industry brown fat Thermogenesis Calcium cycling Adipose Tissue Beige medicine.disease 030104 developmental biology Receptors Adrenergic beta-3 beige fat Anti-Obesity Agents calcium cycling business Signal Transduction |
| Zdroj: | Frontiers in Endocrinology, Vol 11 (2020) Frontiers in Endocrinology |
| ISSN: | 1664-2392 |
| Popis: | Brown fat and beige fat are known as thermogenic fat due to their contribution to non-shivering thermogenesis in mammals following cold stimulation. Beige fat is unique due to its origin and its development in white fat. Subsequently, both brown fat and beige fat have become viable targets to combat obesity. Over the last few decades, most therapeutic strategies have been focused on the canonical pathway of thermogenic fat activation via the β3-adrenergic receptor (AR). Notwithstanding, administering β3-AR agonists often leads to side effects including hypertension and particularly cardiovascular disease. It is thus imperative to search for alternative therapeutic approaches to combat obesity. In this review, we discuss the current challenges in the field with respect to stimulating brown/beige fat thermogenesis. Additionally, we include a summary of other newly discovered pathways, including non-AR signaling- and non-UCP1-dependent mechanisms, which could be potential targets for the treatment of obesity and its related metabolic diseases. |
| Databáze: | OpenAIRE |
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