Multiple intracranial de-novo chloromas presenting with Garcin's syndrome
| Autor: | Ravi Dadlani, Nandita Ghosal, Alangar S. Hegde, Anita Mahadevan, Dilip Jethwani, Sumit Thakar |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Pathology medicine.medical_specialty medicine.medical_treatment Pathology and Forensic Medicine Young Adult Biopsy medicine Myeloid sarcoma Humans Sarcoma Myeloid Chemotherapy medicine.diagnostic_test business.industry Brain Neoplasms General Medicine Syndrome medicine.disease Immunohistochemistry Cranial Nerve Diseases Radiation therapy Skull Leukemia medicine.anatomical_structure Neurology Neurology (clinical) Sarcoma Bone marrow business |
| Zdroj: | Clinical neuropathology. 31(5) |
| ISSN: | 0722-5091 |
| Popis: | Intracranial occurrence of a chloroma (myeloid sarcoma, MS) in the absence of a preceding hematological malignancy is unusual. We report the case of a 20-year-old man who presented with Garcin's syndrome of short duration. MRI revealed multiple extra-axial contrast enhancing lesions: two mirror lesions on the skull base, and one in the right parietal convexity. The parietal lesion was excised and histologically and immunohistochemically proved to be a differentiated variant of MS. Peripheral blood smear and bone marrow biopsy ruled out an underlying leukemia or myeloproliferative disorder. With a diagnosis of intracranial de-novo MS, he was referred for chemotherapy and radiation therapy. 15 months later, his clinical status remained the same while his imaging showed marginal decrease in size of the lesions. A repeat bone marrow biopsy remained normal. This is a first-of-its- kind report of multiple intracranial lesions of a de-novo MS presenting as Garcin's syndrome. Radiological differentials, immunohistochemical variants and management options related to MS are discussed in the light of the reported case. |
| Databáze: | OpenAIRE |
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