Convergent molecular defects underpin diverse neurodegenerative diseases
Autor: | Tofaris, G, Buckley, N |
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Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Parkinson's disease Neurodegeneration Neurodegenerative Diseases Disease Biology medicine.disease 3. Good health 03 medical and health sciences Psychiatry and Mental health 030104 developmental biology Proteostasis Genome editing Huntington's disease medicine Humans Surgery Neurology (clinical) Neuroscience Neuroinflammation Frontotemporal dementia |
Zdroj: | J Neurol Neurosurg Psychiatry |
ISSN: | 1468-330X |
Popis: | In our ageing population, neurodegenerative disorders carry an enormous personal, societal and economic burden. Although neurodegenerative diseases are often thought of as clinicopathological entities, increasing evidence suggests a considerable overlap in the molecular underpinnings of their pathogenesis. Such overlapping biological processes include the handling of misfolded proteins, defective organelle trafficking, RNA processing, synaptic health and neuroinflammation. Collectively but in different proportions, these biological processes in neurons or non-neuronal cells lead to regionally distinct patterns of neuronal vulnerability and progression of pathology that could explain the disease symptomology. With the advent of patient-derived cellular models and novel genetic manipulation tools, we are now able to interrogate this commonality despite the cellular complexity of the brain in order to develop novel therapeutic strategies to prevent or arrest neurodegeneration. Here, we describe broadly these concepts and their relevance across neurodegenerative diseases. |
Databáze: | OpenAIRE |
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