Association between metabolic syndrome and endometrial cancer risk: a systematic review and meta-analysis of observational studies
| Autor: | Zhen-Hua Du, Lan Wang, Jia-Ming Qiao, Song Gao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Aging medicine.medical_specialty Risk Factors Internal medicine medicine Odds Ratio Humans International diabetes federation risk Aged Metabolic Syndrome business.industry Endometrial cancer Cell Biology Odds ratio Middle Aged medicine.disease Confidence interval Endometrial Neoplasms meta-analysis Observational Studies as Topic Increased risk Meta-analysis endometrial cancer Observational study Female Metabolic syndrome business Research Paper |
| Zdroj: | Aging (Albany NY) |
| ISSN: | 1945-4589 |
| Popis: | Existing evidence has revealed inconsistent results on the association between metabolic syndrome (MetS) and endometrial cancer (EC) risk. Herein, we aim to better understand this association. Systematic searches of PubMed, EMBASE, and Web of Science through 12 December 2019 were conducted. Observational studies that provided risk estimates of MetS and EC risk were eligible. The quality of the included studies was judged based on the Newcastle-Ottawa scale. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using a random-effects model. Six studies, comprising 17,772 EC cases and 150,371 participants were included. MetS, diagnosed according to the criteria of the National Cholesterol Education Program-Third Adult Treatment Panel, was associated with an increased risk of EC (OR: 1.62; 95% CI = 1.26-2.07) with substantial heterogeneity (I2 = 78.3%). Furthermore, we found that women with MetS, diagnosed according to the criteria of the International Diabetes Federation, had a significantly higher risk of EC compared to healthy controls (OR: 1.45; 95% CI = 1.16-1.81; I2 = 64.6%). Our findings were generally consistent with the main results in the majority of prespecified subgroups, as well as in sensitivity analyses. In conclusion, MetS is associated with EC risk. |
| Databáze: | OpenAIRE |
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