Pharma‐molecule Transport across Bacterial Membranes: Detection and Quantification Approaches by Electrochemistry and Bioanalytical Methods
| Autor: | Sabine Kuss, Luma Lopes, Alon Golubchik, Vikram Singh |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0303 health sciences
Bioanalysis Bacteria 030306 microbiology Chemistry Electrochemical Techniques General Medicine General Chemistry Computational biology Drug resistance Membrane transport Catalysis Anti-Bacterial Agents 3. Good health 03 medical and health sciences Antibiotic resistance Membrane Drug Resistance Bacterial 030304 developmental biology Drug transport Healthcare system |
| Zdroj: | Angewandte Chemie International Edition. 60:22112-22124 |
| ISSN: | 1521-3773 1433-7851 |
| Popis: | Antibiotic resistance is a significant challenge encountered by healthcare systems on a global scale. Knowledge about membrane transport of antibiotics and other pharmacologically relevant molecules in bacteria is crucial towards understanding and overcoming antibiotic resistance, as drug resistance often depends on drug transport. This comprehensive literature review discusses the detection and quantification of membrane transport of pharma-molecules in bacteria and highlights the importance of molecule transport to antibiotic resistance. This review emphasizes electrochemical and electrophysiological methods of detection and quantification. The results of this literature review reveal a substantial diversity in methods and types of quantitative information collected. |
| Databáze: | OpenAIRE |
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