Methylphenidate produces selective enhancement of declarative memory consolidation in healthy volunteers
| Autor: | Eric F. P. M. Vuurman, Anke Sambeth, A.M.W. Linssen, Wim J. Riedel |
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| Přispěvatelé: | Neuropsychology & Psychopharmacology, RS: FPN NPPP II |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Dopamine EVENT-RELATED POTENTIALS law.invention Reuptake Young Adult Cognition Randomized controlled trial Dopamine Uptake Inhibitors Double-Blind Method law Memory YOUNG-ADULTS medicine Attention deficit hyperactivity disorder Declarative memory consolidation Declarative memory Original Investigation Pharmacology Cross-Over Studies Dose-Response Relationship Drug Methylphenidate TRYPTOPHAN DEPLETION ATTENTION HUMANS PERFORMANCE medicine.disease D-AMPHETAMINE HUMAN BRAIN Crossover study OBJECT LOCATIONS Memory Short-Term SPATIAL WORKING-MEMORY Central Nervous System Stimulants Psychology Neuroscience medicine.drug |
| Zdroj: | Psychopharmacology, 221(4), 611-619. Springer Psychopharmacology |
| ISSN: | 0033-3158 |
| DOI: | 10.1007/s00213-011-2605-9 |
| Popis: | RATIONALE: Methylphenidate inhibits the reuptake of dopamine and noradrenaline and is used to treat children with attention deficit hyperactivity disorder (ADHD). Besides reducing behavioral symptoms, it improves their cognitive function. There are also observations of methylphenidate-induced cognition enhancement in healthy adults, although studies in this area are relatively sparse. We assessed the possible memory-enhancing properties of methylphenidate. OBJECTIVE: In the current study, the possible enhancing effects of three doses of methylphenidate on declarative and working memory, attention, response inhibition and planning were investigated in healthy volunteers. METHODS: In a double blind placebo-controlled crossover study, 19 healthy young male volunteers were tested after a single dose of placebo or 10, 20 or 40 mg of methylphenidate. Cognitive performance testing included a word learning test as a measure of declarative memory, a spatial working memory test, a set-shifting test, a stop signal test and a computerized version of the Tower of London planning test. RESULTS: Declarative memory consolidation was significantly improved relative to placebo after 20 and 40 mg of methylphenidate. Methylphenidate also improved set shifting and stopped signal task performance but did not affect spatial working memory or planning. CONCLUSIONS: To the best of our knowledge, this is the first study reporting enhanced declarative memory consolidation after methylphenidate in a dose-related fashion over a dose range that is presumed to reflect a wide range of dopamine reuptake inhibition. |
| Databáze: | OpenAIRE |
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