Early application of tail nerve electrical stimulation-induced walking training promotes locomotor recovery in rats with spinal cord injury
| Autor: | Mary Gates, S-x Zhang, Eric G. Holmberg, F. Huang, X. Shen |
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| Rok vydání: | 2016 |
| Předmět: |
Tail
0301 basic medicine medicine.medical_specialty Neurology Stimulation Severity of Illness Index Post injury 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation Reflex Animals Medicine Rats Long-Evans Prospective Studies Spinal cord injury Spinal Cord Injuries business.industry Walking test Recovery of Function General Medicine medicine.disease Spinal cord Electric Stimulation Rats Disease Models Animal Electrophysiology 030104 developmental biology medicine.anatomical_structure Exploratory Behavior Original Article Female Neurology (clinical) business Paraplegia Locomotion 030217 neurology & neurosurgery |
| Zdroj: | Spinal Cord |
| ISSN: | 1476-5624 1362-4393 |
| DOI: | 10.1038/sc.2016.30 |
| Popis: | Study design: This is a randomized controlled prospective trial with two parallel groups. Objectives: The objective of this study was to determine whether early application of tail nerve electrical stimulation (TANES)-induced walking training can improve the locomotor function. Setting: This study was conducted in SCS Research Center in Colorado, USA. Methods: A contusion injury to spinal cord T10 was produced using the New York University impactor device with a 25 -mm height setting in female, adult Long–Evans rats. Injured rats were randomly divided into two groups (n=12 per group). One group was subjected to TANES-induced walking training 2 weeks post injury, and the other group, as control, received no TANES-induced walking training. Restorations of behavior and conduction were assessed using the Basso, Beattie and Bresnahan open-field rating scale, horizontal ladder rung walking test and electrophysiological test (Hoffmann reflex). Results: Early application of TANES-induced walking training significantly improved the recovery of locomotor function and benefited the restoration of Hoffmann reflex. Conclusion: TANES-induced walking training is a useful method to promote locomotor recovery in rats with spinal cord injury. |
| Databáze: | OpenAIRE |
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