Arteriolar constriction in mild-to-moderate essential hypertension: an old concept requiring reconsideration?
| Autor: | WF Terpstra, M. E. Gels, Jhj Muntinga, AJ Smit, K. R. Visser, Jtm Vanleeuwen |
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| Přispěvatelé: | Groningen Kidney Center (GKC), Vascular Ageing Programme (VAP) |
| Rok vydání: | 1997 |
| Předmět: |
Adult
Male REFLEX Physiology BLOOD-PRESSURE Blood volume Essential hypertension PARAMETERS RATS VESSELS Internal Medicine medicine Humans electrical impedance Aged business.industry Venous blood Middle Aged medicine.disease NERVOUS-SYSTEM MODEL Compliance (physiology) Arterioles blood volume medicine.anatomical_structure Blood pressure Vasoconstriction Anesthesia Hypertension Vascular resistance SKELETAL-MUSCLE Female medicine.symptom STRUCTURAL-CHANGES Cardiology and Cardiovascular Medicine business arterial compliance RESISTANCE Artery Compliance |
| Zdroj: | Journal of Hypertension, 15(4), 411-419. LIPPINCOTT WILLIAMS & WILKINS |
| ISSN: | 0263-6352 |
| Popis: | Objective To investigate differences between in-vivo properties of a vascular bed in hypertensive patients and normotensive controls, Design Despite the controversy about the origin of essential hypertension and its accompanying vascular changes, it is generally assumed that the characteristic increase in peripheral resistance when hypertension progresses is caused by arteriolar constriction. Yet, there is little experimental evidence that this assumption generally holds in vivo. Methods A non-invasive technique was used for studying properties of the complete vascular bed of an upper arm segment under an occluding cuff in 23 previously untreated hypertensive patients and their matched normotensive controls. The method used the segment's electrical impedance to assess the volumes of extravascular fluid and of arterial and venous blood under varying arterial transmural pressures. Results Compared with that of matched normotensive controls, the compliance of the large arteries of the vascular bed was on average 50.9% lower (P |
| Databáze: | OpenAIRE |
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