Hemostasis Disturbances in Patients in the Acute Period of Isolated Traumatic Brain Injury (Review)
| Autor: | Polupan Aa, Alexander Potapov, I. А. Savin, Oshorov Av, Sychev Aa, A. I. Baranich |
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| Rok vydání: | 2018 |
| Předmět: |
tbi-associated coagulopathy
Traumatic brain injury hemorrhagic foci Brain damage 030204 cardiovascular system & hematology Critical Care and Intensive Care Medicine Systemic inflammation Bioinformatics coagulopathy platelet disfunction microthrombs 03 medical and health sciences 0302 clinical medicine Thrombocytopathy Coagulopathy medicine neurosurgery Coagulation Disorder Disseminated intravascular coagulation RC86-88.9 business.industry traumatic brain injury Medical emergencies. Critical care. Intensive care. First aid tissue factor medicine.disease ischemic foci Hemostasis tbi hemostasis medicine.symptom business microvesicles 030217 neurology & neurosurgery |
| Zdroj: | Obŝaâ Reanimatologiâ, Vol 14, Iss 5, Pp 85-95 (2018) |
| ISSN: | 2411-7110 1813-9779 |
| Popis: | Acute isolated traumatic brain injury (TBI) is frequently associated with occurrence of hemostasis disorders, which may be accompanied with hemorrhagic and ischemic events in the brain matter, hence, normal functioning of the blood coagulation system is critical. Understanding of the pathophysiological mechanisms of this phenomenon might help adequate prophylaxis of secondary brain damage. Earlier, development of disseminated intravascular coagulation syndrome (DIC) has been generally considered as a mechanism of coagulation disorders during TBI. However, over the recent decades, new data emerged concerning the key role of tissue factor, systemic inflammation response, thrombocytopathy, protein C effect in the occurrence of this coagulopathy. This overview of literature is aimed at providing the new data on specific pathophysiological mechanisms underlying coagulopathy following TBI. |
| Databáze: | OpenAIRE |
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