Endothelial Cell-Based Methods for the Detection of Cyanobacterial Anti- Inflammatory and Wound-Healing Promoting Metabolites
| Autor: | Maren Pflueger, Pavel Hrouzek, Alena Lukesova, Christoph Wiesner, Rudolf Lucas, Dalibor Stys, Harald Hundsberger, Christoph Kleber, Barbara Entler, Wolfgang Schuett, Josef Atzler, Jiri Kopecky |
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| Rok vydání: | 2007 |
| Předmět: |
Chemokine
Acute Lung Injury Clinical Biochemistry Anti-Inflammatory Agents Pharmaceutical Science Lung injury Biology Models Biological Cell Line Downregulation and upregulation medicine Humans Pharmacology (medical) Nostoc Wound Healing Biochemistry (medical) In vitro toxicology Endothelial Cells Intercellular Adhesion Molecule-1 medicine.disease Cell biology Pulmonary Alveoli Endothelial stem cell Gene Expression Regulation Neutrophil Infiltration Cell culture biology.protein Wound healing Infiltration (medical) |
| Zdroj: | Drug Metabolism Letters. 1:254-260 |
| ISSN: | 1872-3128 |
| DOI: | 10.2174/187231207783221385 |
| Popis: | Acute lung injury is accompanied by an increased endothelial chemokine production and adhesion molecule expression, which may result in an extensive neutrophil infiltration. Moreover, a destruction of the alveolar epithelium and capillary endothelium may result in permeability edema. As such, the search for novel anti-inflammatory substances, able to downregulate these parameters as well as the tissue damage holds therapeutic promise. We therefore describe here the use of human endothelial cell-based in vitro assays for the detection of anti-inflammatory and wound-healing metabolites from cyanobacteria. |
| Databáze: | OpenAIRE |
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