Detection of New Epitopes of Antibodies to Filaggrin in Filaggrin Protein Molecule
| Autor: | Demkin Vv, M. Yu. Sandin, B. A. Alikhanov, V. I. Kozlova, Alexei N. Nekrasov, A G Kobylyansky |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Amino Acid Motifs
Molecular Sequence Data Arthritis Peptide Filaggrin Proteins General Biochemistry Genetics and Molecular Biology Epitope Arthritis Rheumatoid Epitopes Intermediate Filament Proteins Antigen Sequence Analysis Protein medicine Humans Amino Acid Sequence skin and connective tissue diseases Peptide sequence chemistry.chemical_classification Fibrin Sequence Homology Amino Acid integumentary system biology Chemistry General Medicine medicine.disease Molecular biology Peptide Fragments Epitope mapping Case-Control Studies biology.protein Antibody Epitope Mapping Protein Binding Filaggrin |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 151:615-618 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | Immunogenic characteristics of filaggrin protein molecule as an antigen for antibodies to filaggrin, markers of early rheumatoid arthritis, were studied. Two new peptide motives, possible epitopes for antibodies to filaggrin, were shown in the filaggrin molecule by predictive analysis using programmed algorithms. Only IMG-3 and its cyclic form IMG-4 exhibited antigenic reactivity with sera from rheumatoid arthritis patients, differing significantly from the reactivity with donor sera. The immunogenic characteristics of IMG-3 differed from the characteristics of a previously described epitope. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink