Activin A Release into the Circulation Is an Early Event in Systemic Inflammation and Precedes the Release of Follistatin
| Autor: | David M. de Kretser, David James Phillips, Kristian Lee Jones, Julie Brauman, Nigel P. Groome |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Lipopolysaccharides
Follistatin endocrine system medicine.medical_specialty animal structures Lipopolysaccharide medicine.medical_treatment Enzyme-Linked Immunosorbent Assay Inflammation Biology Systemic inflammation Proinflammatory cytokine chemistry.chemical_compound Endocrinology Internal medicine medicine Animals Inhibins Interleukin 6 Glycoproteins Sheep Interleukin-6 Tumor Necrosis Factor-alpha Activins Cytokine chemistry embryonic structures biology.protein Tumor necrosis factor alpha medicine.symptom hormones hormone substitutes and hormone antagonists |
| Zdroj: | Endocrinology. 141:1905-1908 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/endo.141.5.7531 |
| Popis: | Recent evidence suggests a role for activin A, and its binding protein, follistatin, in inflammatory pathways. However, whether activin is released systemically during inflammation is not known. In this study, a release of activin A into the circulation occurred in sheep within 1 hour of injection of lipopolysaccharide. This rapid peak in activin A preceded the release of the key inflammatory cytokines, tumor necrosis factor-α and interleukin-6. Follistatin release into the circulation occurred some 4 hours after the peak of activin A and continued out to 24 hours from lipopolysaccharide treatment. These data are the first to document a circulatory response of activin A to an inflammatory stimulus, and together with previous findings, suggest that activin A may have both pro- and anti-inflammatory actions in regulating cytokine-driven pathways. |
| Databáze: | OpenAIRE |
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