Polymorphisms of the XRCC1 and XPD genes and breast cancer risk: a case-control study
| Autor: | Ladislav Mirossay, Jana Blažejová, Martina Čižmáriková, Dana Potočeková, Helena Baumohlová, Juraj Bober, Lívia Kipikašová, Marek Šarišský, Ján Mojžiš, Peter Bohus, Andrej Mirossay, Tomáš Wolaschka |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Cancer Research Xeroderma pigmentosum Genotype Single-nucleotide polymorphism Breast Neoplasms Biology Polymorphism Single Nucleotide Pathology and Forensic Medicine Exon Breast cancer medicine Humans Genetic Predisposition to Disease Allele frequency Aged Xeroderma Pigmentosum Group D Protein Genetics Aged 80 and over Chi-Square Distribution Case-control study General Medicine Middle Aged medicine.disease Genotype frequency DNA-Binding Proteins X-ray Repair Cross Complementing Protein 1 Oncology Case-Control Studies Female |
| Zdroj: | Pathology oncology research : POR. 14(2) |
| ISSN: | 1219-4956 |
| Popis: | The purpose of this case control study was to evaluate the role of X-ray repair cross-complementing group 1 (XRCC1) and xeroderma pigmentosum group D (XPD) genotypes as genetic indicators of susceptibility to breast cancer (BC). We analysed DNA samples from 114 breast cancer patients and 113 control subjects using polymerase chain reaction-restriction fragment length polymorphism. For the single nucleotide polymorphisms in XRCC1 exon 10 (Arg399Gln, G/A) and XPD exon 23 (Lys751Gln, A/C), no remarkable differences for genotype distribution and allele frequencies were observed between BC group and control group in the study. The genotype frequency for homozygote A/A in XPD exon 6 (Arg156Arg, C/A) were significantly different between BC and control groups (P < 0.0001, odds ratio = 2.14; 95% confidence interval 1.44-3.17). The data indicate a possible role for XPD (Arg156Arg, C/A) polymorphisms in BC susceptibility. |
| Databáze: | OpenAIRE |
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