Apoptosis in the kidneys of patients with type II diabetic nephropathy
| Autor: | Laura Rimoldi, Franco Ferrario, M. Miji, M. Giannoni, Barbara Villaggio, Giacomo Garibotto, Maria Teresa Gandolfo, Francesco Gianiorio, Giacomo Deferrari, Maria Pia Rastaldi, Daniela Verzola, Francesca Lauria |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Programmed cell death Fas Ligand Protein Biopsy Kidney Glomerulus p38 MAPK Kidney p38 Mitogen-Activated Protein Kinases Fas ligand Nephropathy Diabetic nephropathy Internal medicine Diabetes mellitus medicine Humans Diabetic Nephropathies Kidney surgery fas Receptor Glycated Hemoglobin business.industry urogenital system diabetic nephropathy apoptosis Cholesterol LDL Fas medicine.disease Immunohistochemistry Up-Regulation Endocrinology medicine.anatomical_structure Kidney Tubules Diabetes Mellitus Type 2 anti-ssDNA Nephrology Case-Control Studies Multivariate Analysis diabetes mellitus business Kidney disease Glomerular Filtration Rate |
| Zdroj: | Kidney International. 72(10):1262-1272 |
| ISSN: | 0085-2538 |
| DOI: | 10.1038/sj.ki.5002531 |
| Popis: | The occurrence and extent of apoptosis in the kidneys of patients with diabetic nephropathy is largely unknown. We evaluated apoptosis in renal biopsies obtained from patients with early or advanced type II diabetic nephropathy. Apoptosis was about 6- and 3-fold higher, respectively, in glomeruli and tubules in kidneys of patients with early nephropathy than in the normal kidney and this was not further increased in advanced diabetic nephropathy. Glomerular apoptosis was related directly to hemoglobin A1 c and systolic blood pressure, whereas tubular cell apoptosis correlated to diabetes duration and low-density lipoprotein-cholesterol. Fas, Fas ligand, and p38 mitogen-activated protein kinase expressions were enhanced in glomeruli and tubules; however, this did not correlate with apoptosis. In patients with proteinuria, apoptosis was associated with the subsequent loss of kidney function. When these parameters were subjected to multivariate analysis, only glomerular apoptosis retained a significant independent predictive value. Our findings suggest that apoptosis might be a clinically relevant mechanism of glomerular and tubular cell loss in proteinuric type II diabetic patients. |
| Databáze: | OpenAIRE |
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