Prostaglandin-induced iridial pigmentation in primates
| Autor: | Bahram Resul, Göran Selén, Johan Stjernschantz |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Prostaglandins F
medicine.medical_specialty genetic structures medicine.medical_treatment Eye disease Administration Topical Prostaglandin Iris Biology Dinoprost Dinoprostone Melanosis chemistry.chemical_compound Internal medicine medicine Animals Latanoprost Iris (anatomy) Sympathectomy Pigment Epithelium of Eye Pigmentation disorder Eye Color medicine.disease eye diseases Ophthalmology Macaca fascicularis medicine.anatomical_structure Endocrinology chemistry Iris Diseases Toxicity Prostaglandins F Synthetic Prostaglandins lipids (amino acids peptides and proteins) sense organs Ophthalmic Solutions |
| Zdroj: | Survey of ophthalmology. 41 |
| ISSN: | 0039-6257 |
| Popis: | Latanoprost, a new ocular hypotensive prostaglandin F2 alpha analogue prodrug, was found to induce increased pigmentation of monkey irides in chronic toxicity studies. This prompted us to investigate the effect of naturally occurring prostaglandins on the monkey iris to determine whether this pigmentary effect is unique for latanoprost or whether it is a class effect of prostaglandins. PGF2 alpha-isopropyl ester (IE), PGE2-IE and latanoprost were applied topically to cynomolgus monkey eyes for 18-44 weeks. One eye of each animal was treated, while the other served as control. In addition, latanoprost was applied to sympathectomized monkey eyes. PGF2 alpha-IE, PGE2-IE, as well as latanoprost, induced increased pigmentation in the monkey eye. The first signs of this effect were seen after about two months of treatment. Latanoprost also induced increased pigmentation in sympathectomized eyes. It is concluded that both naturally occurring prostaglandins and their synthetic analogues can induce increased iridial pigmentation in cynomolgus monkeys, and that the effect does not require the presence of sympathetic nerves. |
| Databáze: | OpenAIRE |
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