Seroprevalence of SARS-CoV-2 IgG specific antibodies among healthcare workers in the Northern Metropolitan Area of Barcelona, Spain, after the first pandemic wave

Autor: Bibiana Quirant-Sánchez, Ignacio Blanco, Joan Matllo, Monica Piña, Oriol Estrada, Maria Dolade, Eva Martínez-Cáceres, Jaume Barallat, Gema Fernández-Rivas, Victoria González
Rok vydání: 2020
Předmět:
Male
RNA viruses
Viral Diseases
Coronaviruses
Epidemiology
Physiology
Social Sciences
030204 cardiovascular system & hematology
Antibodies
Viral
Biochemistry
Immunoglobulin G
Geographical locations
0302 clinical medicine
Medical Conditions
Seroepidemiologic Studies
Immune Physiology
Pandemic
Health care
Medicine
030212 general & internal medicine
Medical Personnel
Pathology and laboratory medicine
Geographic Areas
Virus Testing
education.field_of_study
Multidisciplinary
Immune System Proteins
biology
Geography
Middle Aged
Medical microbiology
Europe
Professions
Infectious Diseases
Viruses
Female
SARS CoV 2
Pathogens
Research Article
Urban Areas
Adult
medicine.medical_specialty
Adolescent
SARS coronavirus
Health Personnel
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Science
Immunology
Population
Human Geography
Microbiology
Antibodies
Urban Geography
03 medical and health sciences
Young Adult
Diagnostic Medicine
Environmental health
Humans
Seroprevalence
European Union
education
Pandemics
Medicine and health sciences
Biology and life sciences
SARS-CoV-2
business.industry
Organisms
Viral pathogens
COVID-19
Proteins
Outbreak
Covid 19
Metropolitan area
Microbial pathogens
Spain
People and Places
biology.protein
Earth Sciences
Population Groupings
business
Zdroj: Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
PLoS ONE, Vol 15, Iss 12, p e0244348 (2020)
PLoS ONE
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
ISSN: 1932-6203
Popis: Background The rapid spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) around the world has caused a global pandemic, infecting millions of individuals, with an unprecedented impact in health care systems worldwide. Healthcare workers are one of the risk groups that need to be well protected, due to their strategic role in patient management, presently and in prevention of healthcare needs for future outbreaks. Here, we present the results of the first SARS-CoV-2 seroprevalence study in the Northern Metropolitan Area of Barcelona, Spain. Methods IgG SARS-CoV-2 antibodies were analyzed in serum samples from 7563 healthcare workers of the Northern Metropolitan Area of Barcelona. Samples were collected after the first pandemic wave (from May 4th to May 22nd, 2020) and were analyzed by automated chemiluminescence assays. All samples were tested for IgG anti-S1/S2. Participant samples with negative or equivocal results but with analytical signals above the limit of detection and/or previously confirmed COVID-19 diagnosis were also tested for IgG anti-Nucleocapsid. Results A total of 779 of 7563 (10.3%) healthcare workers were positive for anti-SARS-CoV-2 IgG (specific for either S1/S2 or N antigens). No significant differences were observed between those working at primary care or at the reference hospital. Interestingly, among 341 participants with a confirmed COVID-19 diagnosis, 36 (10.55%) tested negative for SARS-CoV-2 IgG (both S1/S2 and recombinant N antigen). Conclusion Seroprevalence of anti-SARS-CoV-2 IgG in the healthcare workers of the North Metropolitan Area of Barcelona was higher than in the general population in the same geographical area. Safety measures have to be stressed in order to protect these essential workers from future pandemic waves.
Databáze: OpenAIRE
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