Seroprevalence of SARS-CoV-2 IgG specific antibodies among healthcare workers in the Northern Metropolitan Area of Barcelona, Spain, after the first pandemic wave
Autor: | Bibiana Quirant-Sánchez, Ignacio Blanco, Joan Matllo, Monica Piña, Oriol Estrada, Maria Dolade, Eva Martínez-Cáceres, Jaume Barallat, Gema Fernández-Rivas, Victoria González |
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Rok vydání: | 2020 |
Předmět: |
Male
RNA viruses Viral Diseases Coronaviruses Epidemiology Physiology Social Sciences 030204 cardiovascular system & hematology Antibodies Viral Biochemistry Immunoglobulin G Geographical locations 0302 clinical medicine Medical Conditions Seroepidemiologic Studies Immune Physiology Pandemic Health care Medicine 030212 general & internal medicine Medical Personnel Pathology and laboratory medicine Geographic Areas Virus Testing education.field_of_study Multidisciplinary Immune System Proteins biology Geography Middle Aged Medical microbiology Europe Professions Infectious Diseases Viruses Female SARS CoV 2 Pathogens Research Article Urban Areas Adult medicine.medical_specialty Adolescent SARS coronavirus Health Personnel Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Science Immunology Population Human Geography Microbiology Antibodies Urban Geography 03 medical and health sciences Young Adult Diagnostic Medicine Environmental health Humans Seroprevalence European Union education Pandemics Medicine and health sciences Biology and life sciences SARS-CoV-2 business.industry Organisms Viral pathogens COVID-19 Proteins Outbreak Covid 19 Metropolitan area Microbial pathogens Spain People and Places biology.protein Earth Sciences Population Groupings business |
Zdroj: | Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona PLoS ONE, Vol 15, Iss 12, p e0244348 (2020) PLoS ONE r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol instname |
ISSN: | 1932-6203 |
Popis: | Background The rapid spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) around the world has caused a global pandemic, infecting millions of individuals, with an unprecedented impact in health care systems worldwide. Healthcare workers are one of the risk groups that need to be well protected, due to their strategic role in patient management, presently and in prevention of healthcare needs for future outbreaks. Here, we present the results of the first SARS-CoV-2 seroprevalence study in the Northern Metropolitan Area of Barcelona, Spain. Methods IgG SARS-CoV-2 antibodies were analyzed in serum samples from 7563 healthcare workers of the Northern Metropolitan Area of Barcelona. Samples were collected after the first pandemic wave (from May 4th to May 22nd, 2020) and were analyzed by automated chemiluminescence assays. All samples were tested for IgG anti-S1/S2. Participant samples with negative or equivocal results but with analytical signals above the limit of detection and/or previously confirmed COVID-19 diagnosis were also tested for IgG anti-Nucleocapsid. Results A total of 779 of 7563 (10.3%) healthcare workers were positive for anti-SARS-CoV-2 IgG (specific for either S1/S2 or N antigens). No significant differences were observed between those working at primary care or at the reference hospital. Interestingly, among 341 participants with a confirmed COVID-19 diagnosis, 36 (10.55%) tested negative for SARS-CoV-2 IgG (both S1/S2 and recombinant N antigen). Conclusion Seroprevalence of anti-SARS-CoV-2 IgG in the healthcare workers of the North Metropolitan Area of Barcelona was higher than in the general population in the same geographical area. Safety measures have to be stressed in order to protect these essential workers from future pandemic waves. |
Databáze: | OpenAIRE |
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