The spectrum of diabetes in acute and chronic pancreatitis
| Autor: | Søren S. Olesen, Frederico G.S. Toledo, Phil A. Hart |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
mechanisms
type 3c diabetes type 1 diabetes Diabetes Mellitus Type 2/complications Gastroenterology pancreatogenic diabetes Diabetes Mellitus Type 1 Diabetes Mellitus Type 2 Pancreatitis Chronic Acute Disease Diabetes Mellitus Diabetes Mellitus Type 1/complications Humans type 2 diabetes Pancreatitis Chronic/complications |
| Zdroj: | Olesen, S S, Toledo, F G S & Hart, P A 2022, ' The spectrum of diabetes in acute and chronic pancreatitis ', Current opinion in gastroenterology, vol. 38, no. 5, pp. 509-515 . https://doi.org/10.1097/MOG.0000000000000864 |
| Popis: | PURPOSE OF REVIEW: To discuss the spectrum of diabetes related to acute and chronic pancreatitis (which are types of pancreatogenic diabetes) and its overlapping features with type 1 and type 2 diabetes.RECENT FINDINGS: Patients with diabetes related to acute and chronic pancreatitis present clinically within a spectrum of overlapping features with other forms of diabetes. In this spectrum, glucose metabolism alterations range from increased insulin resistance following acute pancreatitis (resembling type 2 diabetes) towards a permanent loss of beta-cell function and impaired insulin secretion in end-stage chronic pancreatitis. Overlapping features with type 1 diabetes (beta cell autoantibodies) and type 2 diabetes (obesity, dyslipidemia, and hereditary/genetic factors) contribute to the heterogeneity of this spectrum.SUMMARY: Pancreatogenic diabetes secondary to acute or chronic pancreatitis is a heterogeneous entity with a variable clinical presentation, including many cases that are misdiagnosed and treated as type 2 diabetes. This is problematic as pancreatogenic diabetes is associated with a poor prognosis and entails special considerations for management. Recent discoveries showing overlapping features with type 1 and type 2 diabetes along with an improved understanding of its pathophysiology are expected to improve the diagnosis and treatment of these and other forms of pancreatogenic diabetes. |
| Databáze: | OpenAIRE |
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