[Effect of Shouwu Shudi Yin on dopaminegic neurons in MPTP induced Parkinson's disease mouse model]
| Autor: | Ahmed Sonauddin, Reginachizi Tunje, Jian-Hong Zhu, Xiong Zhang, Bhugun Hansraj, Sharma Shivani, Sangye Ngawang, Rong-Pei Liu, Yang-Lie Ye |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Parkinson's disease Tyrosine 3-Monooxygenase Mrna expression Substantia nigra 03 medical and health sciences chemistry.chemical_compound Mice Internal medicine medicine Animals Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics chemistry.chemical_classification Glutathione Peroxidase Tyrosine hydroxylase business.industry Glutathione peroxidase MPTP Dopaminergic Neurons Parkinson Disease medicine.disease humanities nervous system diseases Mice Inbred C57BL Substantia Nigra Disease Models Animal Endocrinology nervous system Complementary and alternative medicine chemistry Preventive medication 1-Methyl-4-phenyl-1 2 3 6-tetrahydropyridine Immunohistochemistry 030101 anatomy & morphology business Drugs Chinese Herbal |
| Zdroj: | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 41(18) |
| ISSN: | 1001-5302 |
| Popis: | In order to investigate the effect of Shouwu Shudi Yin on dopaminegic neurons in MPTP induced Parkinson's disease mouse model and the possible mechamism, the experimental mice were randomly divided into 4 groups: control, Shouwu Shudi Yin, MPTP and the treatment (MPTP+Shouwu Shudi Yin) groups. The number of tyrosine hydroxylase (TH) positive cells in the substantia nigra was measured by immunohistochemistry, and mRNA expression of TH and glutathione peroxidase (GPX) were detected by PCR. The results showed that the number of TH positive cells and mRNA expression of TH were significantly reduced in MPTP group compared with the control (P |
| Databáze: | OpenAIRE |
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