Effect of drug and diet treatment of mild hypertension on diastolic blood pressure. The TAIM Research Group
| Autor: | Morton Hawkins, A. Oberman, Neal Zimbaldi, Barry R. Davis, S. Wassertheil-Smoller, Donald Blaufox, Herbert G. Langford |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
medicine.medical_specialty Diet therapy Adrenergic beta-Antagonists Natriuresis Blood Pressure Diastole Weight loss Internal medicine Internal Medicine Humans Medicine Diuretics Thiazide Aged business.industry Body Weight Diet Sodium-Restricted Middle Aged Atenolol Endocrinology Blood pressure Hypertension Potassium Cardiology Regression Analysis Chlorthalidone medicine.symptom business medicine.drug Low sodium |
| Zdroj: | Hypertension. 17:210-217 |
| ISSN: | 1524-4563 0194-911X |
| DOI: | 10.1161/01.hyp.17.2.210 |
| Popis: | The Trial of Antihypertensive Interventions and Management is a multicenter randomized trial designed to examine the diastolic blood pressure response of various combinations of pharmacological and dietary interventions in the treatment of mild hypertension (diastolic blood pressure 90-100 mm Hg). Eight hundred and seventy-eight participants at 110-160% of ideal weight were randomly allocated to nine drug/diet treatment groups receiving either a placebo, chlorthalidone (25 mg), or atenolol (50 mg), combined with a usual, a weight loss, or a low sodium/high potassium diet. The primary outcome was diastolic blood pressure change from baseline to 6 months. Seven hundred and eighty-seven participants had follow-up data. The mean baseline diastolic blood pressure was 93.8 mm Hg; 55.9% of the participants were male, and the weight loss diet group lost an average of 4.7 kg. Multiple comparisons were accounted for in the analysis. A significantly greater lowering of diastolic blood pressure (12.4 mm Hg) was achieved in the atenolol group compared with either the low sodium/high potassium diet group (7.9 mm Hg, p = 0.001) or weight loss group (8.8 mm Hg, p = 0.006). Adding weight loss to chlorthalidone significantly enhanced blood pressure lowering (15.1 mm Hg) when compared with the diuretic alone (10.8 mm Hg, p = 0.002), but adding a low sodium/high potassium diet (12.2 mm Hg, p = 0.029) did not. In the short-term treatment of mild hypertension where diastolic blood pressure is the sole consideration, drugs outperform diet, and weight loss is beneficial, especially with diuretics. |
| Databáze: | OpenAIRE |
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