Knowledge Based Prediction of Ligand Binding Modes and Rational Inhibitor Design for Kinase Drug Discovery
| Autor: | Douglas A. Pippin, Torsten Herbertz, Joseph M. Salvino, Arup K. Ghose, John P. Mallamo |
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| Rok vydání: | 2008 |
| Předmět: |
Drug
media_common.quotation_subject Quantitative Structure-Activity Relationship Pharmacology Ligands chemistry.chemical_compound Drug Discovery medicine Humans Databases Protein Benzamide Phosphorylase kinase Protein Kinase Inhibitors media_common Binding Sites biology Chemistry Drug discovery Kinase Imatinib Biochemistry Drug Design Mitogen-activated protein kinase biology.protein Molecular Medicine Signal transduction medicine.drug |
| Zdroj: | Journal of Medicinal Chemistry. 51:5149-5171 |
| ISSN: | 1520-4804 0022-2623 |
| DOI: | 10.1021/jm800475y |
| Popis: | toward kinase inhibitor discovery, with the result that several kinase inhibitors have been approved as drugs since 2001. The commercial success of imatinib (N-(4-methyl-3-(4-(pyridin-3yl)pyrimidin-2-ylamino)phenyl)-4-((4-methylpiperazin-1-l)methyl)benzamide) has provided a clear incentive for the continued pursuit of kinase inhibitor design. |
| Databáze: | OpenAIRE |
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