Metabolic and clinical responses to different types of premedication in children
| Autor: | Pirkka Rautakorpi, Tuula Manner, Kalle Lertola, Jussi Kanto |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.drug_class Placebo Xerostomia Oxygen Consumption Double-Blind Method Heart Rate Anticholinergic medicine Humans Hypnotics and Sedatives Glycopyrronium bromide Child Glycopyrrolate business.industry Hemodynamics Carbon Dioxide Pethidine Atropine Anesthesiology and Pain Medicine Anesthesia Injections Intravenous Pediatrics Perinatology and Child Health Female Premedication Energy Metabolism business Diazepam Preanesthetic Medication medicine.drug |
| Zdroj: | Pediatric Anesthesia. 9:387-392 |
| ISSN: | 1460-9592 1155-5645 |
| DOI: | 10.1046/j.1460-9592.1999.00369.x |
| Popis: | The metabolic and clinical responses to intravenously administered atropine + meperidine (pethidine), glycopyrrolate + meperidine, diazepam and placebo were examined in 76 healthy children. After atropine + meperidine and glycopyrrolate + meperidine administration, a significant antisialogogue effect, tachycardia and elevation in systolic blood pressure were observed. Diazepam decreased oxygen consumption (VO 2 ) whereas atropine + meperidine increased both VO 2 and energy expenditure (EE). The maximal effect of diazepam on VO 2 was found 10 min after drug administration (mean difference from baseline -10.0%) and maximal effect of atropine+meperidine on VO 2 and EE after 5 min (mean difference from baseline +6.0% and +3.3%, respectively). It is concluded that intravenous administration of meperidine with atropine or glycopyrrolate is followed by profound anticholinergic effects and such combinations do not appear to be suitable for clinical purposes. Although statistically significant, the alterations in VO 2 and EE after diazepam and atropine+meperidine premedication can be considered clinically insignificant because they were of short duration and the measured changes represented only a fraction of fluctuation seen in normal values. |
| Databáze: | OpenAIRE |
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