Nano-Strategies for Improving the Bioavailability of Inhaled Pharmaceutical Formulations
| Autor: | Zhifeng Xue, Zhidong Liu, Peng Lu, Bing Zhang, Yue Xing, Dereje Kebebe, Chunxia Liang, Hongfei Liu |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Drug
Lung Diseases Polymers media_common.quotation_subject Drug Compounding Biological Availability 02 engineering and technology Pharmacology 030226 pharmacology & pharmacy 03 medical and health sciences 0302 clinical medicine Anti-Infective Agents Drug Discovery Administration Inhalation Medicine Humans Solubility media_common Polymer-drug conjugates Drug Carriers business.industry General Medicine 021001 nanoscience & nanotechnology Bioavailability Inhalation preparations Pharmaceutical Preparations Drug delivery Nanoparticles Nanocarriers 0210 nano-technology business Clearance |
| Zdroj: | Mini reviews in medicinal chemistry. 20(13) |
| ISSN: | 1875-5607 |
| Popis: | Pulmonary pharmaceutical formulations are targeted for the treatment of respiratory diseases. However, their application is limited due to the physiological characteristics of the lungs, such as branching structure, mucociliary and macrophages, as well as certain properties of the drugs like particle size and solubility. Nano-formulations can ameliorate particle sizes and improve drug solubility to enhance bioavailability in the lungs. The nano-formulations for lungs reviewed in this article can be classified into nanocarriers, no-carrier-added nanosuspensions and polymer-drug conjugates. Compared with conventional inhalation preparations, these novel pulmonary pharmaceutical formulations have their own advantages, such as increasing drug solubility for better absorption and less inflammatory reaction caused by the aggregation of insoluble drugs; prolonging pulmonary retention time and reducing drug clearance; improving the patient compliance by avoiding multiple repeated administrations. This review will provide the reader with some background information for pulmonary drug delivery and give an overview of the existing literature about nano-formulations for pulmonary application to explore nano-strategies for improving the bioavailability of pulmonary pharmaceutical formulations. |
| Databáze: | OpenAIRE |
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