Local Resection of Primary Tumor in Upfront Stage IV Breast Cancer
| Autor: | Sven Mahner, Rachel Wuerstlein, Thomas Kolben, Nadia Harbeck, Steffen Kahlert, Theresa M. Kolben, Isabelle Himsl, Tom Degenhardt, Jutta Engel |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Local resection business.industry Cancer medicine.disease Primary tumor Metastatic breast cancer 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Breast cancer 030220 oncology & carcinogenesis Internal medicine Overall survival Medicine Original Article Surgery business Stage iv |
| Zdroj: | Breast Care. 11:411-417 |
| ISSN: | 1661-3805 1661-3791 |
| DOI: | 10.1159/000453573 |
| Popis: | Background: This study aimed to identify the association of local surgery of the primary tumor in metastatic breast cancer (MBC) patients with overall survival (OS) and prognostic factors. Patients and Methods: Patients with primary MBC (1990-2006) were included in our retrospective analysis (n = 236). 83.1% had surgery for the primary tumor. OS was evaluated using Kaplan-Meier estimates. Predictive factors for OS were determined. Results: Median follow-up was 123 months for all patients still alive at the time of analysis. In univariate analysis, patients with surgery of the primary tumor had significantly prolonged OS (28.9 vs. 23.9 months). Within the surgery group, patients with MBC limited to 1 organ system had a better outcome (39.3 vs. 24.9 months), as did asymptomatic patients. Independent risk factors for shorter OS were hormone receptor negativity, symptoms, and involvement of ≥ 1 organ system. Conclusion: Patient selection for local therapy was confounded by a more favorable profile and a lesser tumor burden before surgery, which might implicate a bias. Nevertheless, our univariate results indicate that local surgery of the primary tumor in MBC patients could be considered as part of the therapeutic regimen in selected patients. However, larger patient numbers are needed to prove these findings in the multivariate model. |
| Databáze: | OpenAIRE |
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