Super‐Resolution Microscopy: Hypotonic Stress Induces Fast, Reversible Degradation of the Vimentin Cytoskeleton via Intracellular Calcium Release (Adv. Sci. 18/2019)
| Autor: | Manni He, Fen Hu, Wan Li, Jingjun Xu, Rui Yan, Ke Xu, Leiting Pan, Ping Zhang |
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| Rok vydání: | 2019 |
| Předmět: |
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biology Chemistry Super-resolution microscopy General Chemical Engineering vimentin intermediate filaments General Engineering General Physics and Astronomy Medicine (miscellaneous) Calpain Vimentin super‐resolution microscopy Biochemistry Genetics and Molecular Biology (miscellaneous) Calcium in biology Hypotonic Stress cytoskeletal ultrastructure biology.protein Biophysics Degradation (geology) General Materials Science Cytoskeleton calpains intracellular calcium release hypotonic stress |
| Zdroj: | Advanced Science |
| ISSN: | 2198-3844 |
| DOI: | 10.1002/advs.201970112 |
| Popis: | In article number 1900865, Ke Xu and co‐workers report, through super‐resolution microscopy, an unexpected, fast degradation pathway of the vimentin cytoskeletal system under hypo‐osmotic stress. Together with calcium imaging and biochemical analysis, the study further unveils that this degradation is due to proteolysis by the calcium‐dependent protease calpain, activated by hypotonic stress‐induced calcium release from intracellular stores. |
| Databáze: | OpenAIRE |
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