Pharmacology of propylthiouracil (PTU) in pregnant hyperthyroid women: correlation of maternal PTU concentrations with cord serum thyroid function tests
| Autor: | Patricia M. Hays, David S. Cooper, Dwight P. Cruikshank, David F. Gardner |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Pregnancy Trimester Third Clinical Biochemistry Pharmacology Biochemistry Umbilical cord Thyroid function tests Hyperthyroidism Endocrinology Pregnancy Reference Values Internal medicine Medicine Humans medicine.diagnostic_test business.industry Antithyroid agent Biochemistry (medical) Postpartum Period Area under the curve medicine.disease Fetal Blood Pregnancy Complications Thyroxine medicine.anatomical_structure Propylthiouracil Gestation Female business hormones hormone substitutes and hormone antagonists Postpartum period medicine.drug |
| Zdroj: | The Journal of clinical endocrinology and metabolism. 62(1) |
| ISSN: | 0021-972X |
| Popis: | Previous studies have characterized the pharmacology of propylthiouracil (PTU) in normal and hyperthyroid subjects, but there is little information available regarding PTU pharmacokinetics in pregnant hyperthyroid women. We investigated the serum PTU response to an oral dose of PTU in six hyperthyroid pregnant women both ante- and postpartum. The serum PTU profile during the third trimester of pregnancy was qualitatively similar to that in nonpregnant subjects, but serum PTU concentrations were consistently lower in the late third trimester compared with postpartum values. Cord serum PTU concentrations were consistently higher than simultaneously obtained maternal serum PTU concentrations, suggesting slower PTU clearance in the fetus. There was a significant inverse correlation (r = -0.92; P = 0.026) between the maternal serum PTU area under the curve in the third trimester and the cord serum free T4 index. |
| Databáze: | OpenAIRE |
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