Fatal SARS-CoV-2 Inflammatory Syndrome and Myocarditis in an Adolescent: A Case Report
| Autor: | Meghan Bernier, Jody E. Hooper, Leonard Feldman, Jeanette T. Beaudry, Julie E. Stein, Jennifer Schuette, Barbara Dietrick, Heba H. Mostafa, Dawn Brianna Lammert, John Hammond, Matthew Buendia, Andrew Pekosz, Allison L. Agwu, Julia McCaw, Alexander Constas |
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| Rok vydání: | 2020 |
| Předmět: |
Microbiology (medical)
2019-20 coronavirus outbreak Pediatrics medicine.medical_specialty Myocarditis Adolescent Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Disease Article 03 medical and health sciences 0302 clinical medicine 030225 pediatrics medicine Humans Decompensation Pediatrics Perinatology and Child Health 030212 general & internal medicine SARS-CoV-2 business.industry COVID-19 medicine.disease Systemic Inflammatory Response Syndrome Black or African American Systemic inflammatory response syndrome Intensive Care Units Infectious Diseases Pediatrics Perinatology and Child Health Female business |
| Zdroj: | Pediatric Infectious Disease Journal Pediatr Infect Dis J |
| ISSN: | 0891-3668 |
| Popis: | BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), an entity in children initially characterized by milder case presentations and better prognoses as compared with adults. Recent reports, however, raise concern for a new hyperinflammatory entity in a subset of pediatric COVID-19 patients. METHODS: We report a fatal case of confirmed COVID-19 with hyperinflammatory features concerning for both multi-inflammatory syndrome in children (MIS-C) and primary COVID-19. RESULTS: This case highlights the ambiguity in distinguishing between these two entities in a subset of pediatric patients with COVID-19-related disease and the rapid decompensation these patients may experience. CONCLUSIONS: Appropriate clinical suspicion is necessary for both acute disease and MIS-C. SARS-CoV-2 serologic tests obtained early in the diagnostic process may help to narrow down the differential but does not distinguish between acute COVID-19 and MIS-C. Better understanding of the hyperinflammatory changes associated with MIS-C and acute COVID-19 in children will help delineate the roles for therapies, particularly if there is a hybrid phenotype occurring in adolescents. |
| Databáze: | OpenAIRE |
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