High-Performance Implantable Bioelectrodes with Immunocompatible Topography for Modulation of Macrophage Responses

Autor:	Sanghun Lee, Junggeon Park, Semin Kim, Jehyung Ok, Jung Il Yoo, Yong Sook Kim, Youngkeun Ahn, Tae-il Kim, Heung Cho Ko, Jae Young Lee
Rok vydání:	2022
Předmět:	Polymers Macrophages Electric Conductivity General Engineering General Physics and Astronomy Pyrroles General Materials Science Electrodes Implanted
Zdroj:	ACS Nano. 16:7471-7485
ISSN:	1936-086X 1936-0851
Popis:	Implantable bioelectrodes enable precise recording or stimulation of electrical signals with living tissues in close contact. However, their performance is frequently compromised owing to inflammatory tissue reactions, which macrophages either induce or resolve by polarizing to an inflammatory (M1) or noninflammatory (M2) phenotype, respectively. Thus, we aimed to fabricate biocompatible and functional implantable conductive polymer bioelectrodes with optimal topography for the modulation of macrophage responses. To this end, we produced heparin-doped polypyrrole (PPy/Hep) electrodes of different surface roughness, with
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cf4a8b2ac2f12736c56f6ba9b0480ff https://doi.org/10.1021/acsnano.1c10506 Zobrazit plný text záznamu